Anaphylaxis to aprotinin in fibrin sealant
Anaphylaxis to aprotinin in fibrin sealant
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DOI：
10.2169/internalmedicine.44.1088
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发表时间：
2005-10-01
影响因子：
1.2
通讯作者：
Yasueda, H
中科院分区：
文献类型：
--
作者：
Shirai, T;Shimota, H;Yasueda, H
一名50岁男性，患有慢性中耳炎，入院检查肺癌。在 12 个月的时间里，他在鼓膜成形术中接受了 7 次纤维蛋白密封剂 (Bolheal) 的重复滴注。在下肺叶切除术中，应用纤维蛋白封闭剂封闭支气管胸膜瘘后不久，收缩压降至60 mmHg。需要接受肾上腺素和多巴胺治疗，直到两天后病情好转。对含有牛抑肽酶的纤维蛋白原和因子 XIII 的溶液检测到特异性 IgE 抗体。通过竞争性 ELISA 抑制测试注意到纯化的抑肽酶和溶液之间的交叉反应。
A 50-year-old man with chronic otitis media was admitted to our hospital for investigation of lung cancer. He had received repeated instillations of fibrin sealant (Bolheal) in myringoplasty 7 times over 12 months. During the lower lobectomy, soon after fibrin sealant was applied to seal bronchopleural fistulas, systolic blood pressure decreased to 60 mmHg. Treatment with epinephrine and dopamine was required until his condition improved 2 days later. The specific IgE antibody was detected for the solution for fibrinogen and factor XIII containing bovine aprotinin. Cross-reactivity between purified aprotinin and the solution was noted by competitive ELISA inhibition tests.