Direct feedback of androgens: localized effects of intrapituitary implants of androgens on gonadotrophic cells and hormone stores.
Direct feedback of androgens: localized effects of intrapituitary implants of androgens on gonadotrophic cells and hormone stores.
复制标题
雄激素的直接反馈：垂体内植入雄激素对促性腺细胞和激素储备的局部影响。
作者：
T. R. Kingsley;E. M. Bogdanove
在去势大鼠一侧垂体内植入含有85%丙酸睾丸酮(TP)、85%二氢睾酮苯甲酸酯(DHTB)或2.5(或5%7-α-甲基-19-去甲睾酮醋酸酯(7αMe))的微丸，可逆转去势细胞的发育，2)增加垂体内促黄体生成素/促黄体生成素比率(通过降低促黄体生成素或通过增加垂体促性腺激素浓度，或两者兼而有之)。这些影响是局部性的：组织学变化仅限于植入的邻近区域，同侧的黄体生成素和卵泡刺激素的变化比对侧更明显，附性器官(精囊和腹侧前列腺体)保持完全或几乎不受刺激。同样放置的含有胆固醇或黄体酮的微丸没有显著效果。皮下植入3个、6个或9个促雄激素颗粒，即使释放足够的雄激素来刺激性附件，也不能产生垂体腺内的变化。皮下注射更大量的雄激素。
In orchidectomized rats, unilateral intrapituitary implants of micropellets containing 85% testosterone propionate (TP), 85% dihydrotestosterone benzoate (DHTB), or 2½( or 5% 7α-methyl-19-nortestosterone acetate (7αMe) acted to; 1) reverse castration cell development and 2) increase intrapituitary FSH/LH ratios (either by lowering LH or by increasing pituitary FSH concentration, or both). The effects were localized: histological changes were restricted to regions contiguous to the implants, changes in LH and FSH were more pronounced ipsilaterally than contralaterally, and accessory sex organs (seminal vesicles and ventral prostate glands) remained completely or virtually unstimulated. Similarly placed micropellets containing cholesterol or progesterone had no significant effect. Subcutaneous implantation of 3, 6, or 9 androgenic pellets failed to produce intrapituitary changes, even if enough androgen was released to stimulate the sex accessories. Subcutaneous injection of larger amounts of these androgen...