INFLUENCE OF OVARIECTOMY, ESTRADIOL AND PROGESTERONE ON THE BEHAVIOR OF MICE IN AN EXPERIMENTAL-MODEL OF DEPRESSION
INFLUENCE OF OVARIECTOMY, ESTRADIOL AND PROGESTERONE ON THE BEHAVIOR OF MICE IN AN EXPERIMENTAL-MODEL OF DEPRESSION
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DOI：
10.1016/0031-9384(89)90238-2
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发表时间：
1989-05-01
影响因子：
2.9
通讯作者：
BERTOLINI, A
中科院分区：
文献类型：
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作者：
BERNARDI, M;VERGONI, AV;BERTOLINI, A
在尾部悬吊实验(抑郁症动物模型)中，观察6分钟的不动持续时间为56.84±-。假去卵巢小鼠6.54秒，113.11.+-。7.86秒，于卵巢切除后30-32天。实验前每天4次皮下注射雌二醇(10,100或1000微克/公斤)和孕酮(50,1000或10,000微克/公斤)，可使去卵巢小鼠的不动时间恢复到正常，而对假手术动物没有影响。另一方面，地塞帕明(测试前1小时ip 20 mg/kg)显著缩短了去卵巢和假手术小鼠的不动时间。这些数据表明，卵巢性激素，虽然没有“抗抑郁剂”，地塞帕明，对正常成年雌性小鼠的行为有影响，但在去卵巢的小鼠身上有这样的效果，使动物能够以一种“正常”的方式应对不利的环境情况。
In the tail suspension test (an animal model of depression) the duration of immobility during the 6 min of observation was 56.84 .+-. 6.54 sec in sham-ovariectomized mice and 113.11 .+-. 7.86 sec 30-32 days after ovariectomy. Estradiol (10, 100 or 1000 .mu.g/kg) and progesterone (50, 1000 or 10,000 .mu.g/kg), subcutaneously injected daily 4 times before the test, restored the duration of immobility in ovariectomized mice to normal, while having no effect on sham-operated animals. On the other hand, desipramine (20 mg/kg IP 1 hr before testing) significantly reduced the duration of immobility both in ovariectomized and in sham-operated mice. These data indicate that ovarian sex hormones, while having no "antidepressant", desipramine-like, effect on the behavior of intact adult female mice, have such an effect in ovariectomized mice, and enable the animal to cope in a "normal" way with adverse environmental situations.