Hypothalamic-Pituitary-Adrenal Axis Modulation of Glucocorticoids in the Cardiovascular System.
Hypothalamic-Pituitary-Adrenal Axis Modulation of Glucocorticoids in the Cardiovascular System.
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DOI：
10.3390/ijms18102150
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发表时间：
2017-10-16
影响因子：
5.6
通讯作者：
Cruz-Topete D
中科院分区：
文献类型：
--
作者：
Burford NG;Webster NA;Cruz-Topete D
发挥动态平衡调节作用的内分泌器官集合--称为下丘脑-垂体-肾上腺(HPA)轴--包括中枢神经系统和外周组织的整合。这些器官对迫在眉睫或感知到的威胁做出反应，引起应激反应，主要是通过肾上腺将糖皮质激素释放到全身循环中。虽然糖皮质激素的分泌在典型的手术中起到了保护和维持体内平衡的作用，但不适当的调节可能会导致生理和心理病理。心血管系统特别容易受到HPA轴和糖皮质激素产生长期失调的影响。关于心血管健康风险是否源于应激轴激活的直接有害影响，或者病理是否继发于伴随的过量糖皮质激素的代谢压力，存在争议。在这篇综述中，我们将探讨新的研究表明，应激确实通过激活HPA轴对心血管系统产生直接影响，重点是糖皮质激素信号在血管和心脏中的影响的最新研究。
The collective of endocrine organs acting in homeostatic regulation—known as the hypothalamic-pituitary-adrenal (HPA) axis—comprises an integration of the central nervous system as well as peripheral tissues. These organs respond to imminent or perceived threats that elicit a stress response, primarily culminating in the release of glucocorticoids into the systemic circulation by the adrenal glands. Although the secretion of glucocorticoids serves to protect and maintain homeostasis in the typical operation at baseline levels, inadequate regulation can lead to physiologic and psychologic pathologies. The cardiovascular system is especially susceptible to prolonged dysregulation of the HPA axis and glucocorticoid production. There is debate about whether cardiovascular health risks arise from the direct detrimental effects of stress axis activation or whether pathologies develop secondary to the accompanying metabolic strain of excess glucocorticoids. In this review, we will explore the emerging research that indicates stress does have direct effects on the cardiovascular system via the HPA axis activation, with emphasis on the latest research on the impact of glucocorticoids signaling in the vasculature and the heart.
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影响因子：
4.8
作者：
Boston, BA;Cone, RD
通讯作者：
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影响因子：
8.3
作者：
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通讯作者：
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影响因子：
4.6
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.1
作者：
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通讯作者：
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