Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.
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脂氧合酶和环氧酶代谢：治疗和化学预防胰腺癌的新见解。
DOI：
10.1186/1476-4598-2-10
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发表时间：
2003-01-07
期刊：
影响因子：
37.3
通讯作者：
Adrian, Thomas E
中科院分区：
文献类型：
--
作者：
Ding, Xian-Zhong;Hennig, Rene;Adrian, Thomas E
必需脂肪酸亚油酸和花生四烯酸在胰腺癌的发生和发展中起重要作用。这些脂肪酸通过环氧合酶和脂氧合酶代谢为类二十烷酸。胰腺癌中环氧合酶和脂氧合酶的异常表达和活性均有报道。在这篇文章中，我们的目的是提供一个简短的总结（1）我们的理解，这些酶在胰腺癌肿瘤的发生和发展的作用;和（2）使用环氧合酶和脂氧合酶抑制剂胰腺癌的治疗和预防的潜力。
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.