Aortic Size Assessment by Noncontrast Cardiac Computed Tomography: Normal Limits by Age, Gender, and Body Surface Area
Aortic Size Assessment by Noncontrast Cardiac Computed Tomography: Normal Limits by Age, Gender, and Body Surface Area
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DOI：
10.1016/j.jcmg.2007.11.005
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发表时间：
2008-03-01
影响因子：
14
通讯作者：
Berman, Daniel S.
中科院分区：
文献类型：
--
作者：
Wolak, Arik;Gransar, Heidi;Berman, Daniel S.
目的：在大量无症状、低风险成人受试者中确定升、降胸主动脉直径的正常范围。背景：通过门控非对比计算机断层扫描（CT）测量冠状动脉钙，可以评估主动脉大小。然而，这些研究的主动脉大小的正常范围尚未被defined.METHODS在4,039例成人患者进行冠状动脉钙（CAC）扫描，升，降胸主动脉直径的系统测量在肺动脉分叉的水平。采用多元线性回归分析检测与升主动脉和降主动脉直径独立相关的风险因素，并从最终分析中排除具有这些参数的受试者。升主动脉和降主动脉的最终分析组分别包括2，952例和1，931例受试者。然后将受试者分别按性别、年龄和升主动脉和降主动脉的体表面积（BSA）重新分组，并计算每组的主动脉直径和主动脉横截面积的平均值、标准差和正常上限。此外，线性回归模型被用来创建BSA与主动脉直径诺模图的年龄组，和一个公式，用于计算预测的主动脉大小的年龄，性别，和BSA created.RESULTS年龄，BSA，性别，和高血压直接与胸主动脉尺寸。此外，糖尿病与升主动脉直径相关，吸烟与降主动脉直径相关。最终分析组的平均直径分别为升主动脉33 +/- 4 mm和降主动脉24 +/- 3 mm。相应的正常直径上限分别为41和30 mm。结论在接受CAC扫描的大量低风险受试者人群中，通过非对比剂门控心脏CT测量的升主动脉和降主动脉尺寸的正常限值已根据年龄、性别和BSA定义。（美国科尔心脏病学杂志2008; 1：200-9）（C）美国心脏病学会基金会2008年
OBJECTIVES To determine normal limits for ascending and descending thoracic aorta diameters in a large population of asymptomatic, low-risk adult subjects.BACKGROUND Assessment of aortic size is possible from gated noncontrast computed tomography (CT) scans obtained for coronary calcium measurements. However, normal limits for aortic size by these studies have yet to be defined.METHODS In 4,039 adult patients undergoing coronary artery calcium (CAC) scanning, systematic measurements of the ascending and descending thoracic aorta diameters were made at the level of the pulmonary artery bifurcation. Multiple linear regression analysis was used to detect risk factors independently associated with ascending and descending thoracic aorta diameter and exclude subjects with these parameters from the final analysis. The final analysis groups for ascending and descending thoracic aorta included 2,952 and 1,931 subjects, respectively. Subjects were then regrouped by gender, age, and body surface area (BSA) for ascending and descending aorta, separately, and for each group, the mean, standard deviation, and upper normal limit were calculated for aortic diameter as well as for the calculated cross-sectional aortic area. Also, linear regression models were used to create BSA versus aortic diameter nomograms by age groups, and a formula for calculating predicted aortic size by age, gender, and BSA was created.RESULTS Age, BSA, gender, and hypertension were directly associated with thoracic aorta dimensions. Additionally, diabetes was associated with ascending aorta diameter, and smoking was associated with descending aorta diameter. The mean diameters for the final analysis group were 33 +/- 4 mm for the ascending and 24 +/- 3 mm for the descending thoracic aorta, respectively. The corresponding upper limits of normal diameters were 41 and 30 mm, respectively.CONCLUSIONS Normal limits of ascending and descending aortic dimensions by noncontrast gated cardiac CT have been defined by age, gender, and BSA in a large, low-risk population of subjects undergoing CAC scanning. (J Am Coll Cardiol Img 2008; 1: 200-9) (C) 2008 by the American College of Cardiology Foundation