Arginine in asthma and lung inflammation
Arginine in asthma and lung inflammation
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DOI：
10.1093/jn/134.10.2830s
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发表时间：
2004-10-01
影响因子：
4.2
通讯作者：
Zimmermann, N
中科院分区：
文献类型：
--
作者：
King, NE;Rothenberg, ME;Zimmermann, N
哮喘是一种复杂的慢性炎症性肺疾病，尽管正在进行的紧张研究强调了新的科学研究的必要性，但它仍在上升。利用全球芯片分析，我们最近发现哮喘反应涉及精氨酸酶对精氨酸的代谢。我们发现，在过敏原诱导的基因转录本中，阳离子氨基酸转运体(CAT)2、精氨酸酶I和精氨酸酶II尤为突出。这些基因分别是与哮喘相关的关键过程的关键调节因子，包括气道张力、细胞增殖和胶原沉积。最近的数据表明，精氨酸酶的诱导不仅是过敏性呼吸道反应的一个标志，而且精氨酸酶参与了疾病的多个方面的发病机制。现就L-精氨酸代谢在哮喘中的研究进展作一综述。
Asthma, a complex chronic inflammatory pulmonary disorder, is on the rise despite intense ongoing research underscoring the need for new scientific inquiry. Using global microarray analysis, we recently discovered that asthmatic responses involve metabolism of arginine by arginase. We found that the cationic amino acid transporter (CAT)2, arginase I, and arginase II were particularly prominent among the allergen-induced gene transcripts. These genes are key regulators of critical processes associated with asthma, including airway tone, cell hyperplasia, and collagen deposition, respectively. Recent data suggest that arginase induction is not just a marker of allergic airway responses, but that arginase is involved in the pathogenesis of multiple aspects of disease. This review focuses on the current body of knowledge on L-arginine metabolism in asthma.