F-18-2-Fluoro-2-Deoxyglucose Positron Emission Tomography Compared to Technetium-99m Hexakis-2-Methoxyisobutyl Isonitrile Single Photon Emission Chest Tomography in the Diagnosis of Indeterminate Lung Lesions
F-18-2-Fluoro-2-Deoxyglucose Positron Emission Tomography Compared to Technetium-99m Hexakis-2-Methoxyisobutyl Isonitrile Single Photon Emission Chest Tomography in the Diagnosis of Indeterminate Lung Lesions
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F-18-2-氟-2-脱氧葡萄糖正电子发射断层扫描与 Technetium-99m Hexakis-2-甲氧基异丁基异腈单光子发射胸部断层扫描在诊断不确定肺部病变中的比较
作者：
M. Santini;A. Fiorelli;G. Vicidomini;Paolo Laperuta;L. Busiello;P. Rambaldi;L. Mansi;A. Rotondo
背景：<sup>18</sup>FDG-PET在诊断肺部恶性病变中起着重要作用，但在意大利有限的几个地点仍然是一种昂贵的测试。目的：我们前瞻性地比较<sup>99 mTc-MIBI</sup>- SPECT和<sup>18FDG-PET</sup>在不确定肺部病变患者中的诊断准确性，以证明当<sup>18FDG-PET</sup>不可用时，<sup>99 mTc-MIBI</sup>-SPECT可被视为有效的替代方法。方法：对52例肺部可疑病变患者术前行<sup>18FDG</sup>PET和<sup>99 mTc-MIBI</sup>-SPECT检查。影像学检查结果进行了视觉和半定量分析，然后与明确的诊断。结果：恶性病变38例，良性病变14例。在视觉分析中，<sup>18FDG-PET</sup>和<sup>99 mTc-MIBI</sup>-SPECT的灵敏度分别为92%和84%（McNemar检验p = 0.4），而特异性分别为78.6%和93%（p = 1.0）。在半定量分析中，<sup>18</sup>FDG-PET显示的灵敏度和特异性分别为92%和71.4%，而<sup>99 mTc-MIBI</sup>-SPECT产生的灵敏度和特异性分别为86%和100%（p = 0.194）。对于淋巴结分期，<sup>18FDG-PET</sup>和<sup>99 mTc-MIBI</sup>-SPECT的敏感性和特异性分别为88和92，分别为77%和100%。结论：<sup>99 mTc-MIBI</sup>-SPECT在检测肺部恶性肿瘤方面与18FDG-PET相似，是PET不可用时的替代方法。<sup></sup>然而，这两种技术的结合可能会改善手术患者的选择。
Background:<sup>18</sup>FDG-PET plays a significant role in diagnosing malignancy of lung lesions but remains an expensive test available at a limited number of sites in Italy. Objective: We prospectively compare the diagnostic accuracy of <sup>99m</sup>Tc-MIBI- SPECT and <sup>18</sup>FDG-PET in patients with indeterminate lung lesions to demonstrate that <sup>99m</sup>Tc-MIBI-SPECT may be considered as a valid alternative when <sup>18</sup>FDG-PET is not available. Methods: 52 patients with indeterminate lung lesion were examined by <sup>18</sup>FDG-PET and <sup>99m</sup>Tc-MIBI-SPECT before surgery. The scintigraphic findings were analyzed visually and semiquantitatively and then correlated to the definitive diagnosis. Results: 38 were malignant lesions while 14 were benign. At visual analysis, the sensitivities of <sup>18</sup>FDG-PET and <sup>99m</sup>Tc-MIBI-SPECT were 92 and 84%, respectively (McNemar test p = 0.4), whereas the specificities were 78.6 and of 93% (p = 1.0), respectively. At semiquantitative analysis, <sup>18</sup>FDG-PET showed a sensitivity and specificity of 92 and 71.4%, respectively, while <sup>99m</sup>Tc-MIBI-SPECT produced a sensitivity and specificity of 86 and 100%, respectively (p = 0.194). For lymph node staging, <sup>18</sup>FDG-PET and <sup>99m</sup>Tc-MIBI-SPECT have a sensitivity and specificity of 88 and 92 of 77 and 100%, respectively. Conclusion:<sup>99m</sup>Tc-MIBI-SPECT is similar to <sup>18</sup>FDG-PET in the detection of lung malignancies and represents an alternative when PET is not available. Yet, the combination of both techniques may improve patient selection for surgery.
缺血和缺血后功能障碍对锝99m标记的甲氧基异丁基异腈和铊201心肌摄取的影响。
影响因子：
24
作者：
Sinusas,AJ;Watson,DD;CannonJr,JM;Beller,GA
通讯作者：
Beller,GA
DOI：
10.1007/s00259-002-0924-0
发表时间：
2002-12-01
影响因子：
9.1
作者：
Hickeson, M;Yun, MJ;Alavi, A
通讯作者：
Alavi, A