METABOLISM OF D- AND L-LYSINE IN CHICKEN
METABOLISM OF D- AND L-LYSINE IN CHICKEN
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DOI：
10.1016/0003-9861(71)90473-5
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发表时间：
1971-01-01
影响因子：
3.9
通讯作者：
ROGHAIR, HG
中科院分区：
文献类型：
--
作者：
GROVE, JA;ROGHAIR, HG
用14c和15n标记法研究了鸡体内d-赖氨酸和l-赖氨酸的代谢。与大鼠相反，鸡积极代谢赖氨酸和胡椒酸酯。数据表明，d-赖氨酸通过转化为pipolate， α-氨基己二酸，α-酮己二酸，最终转化为CO2。赖氨酸的α-氮原子是通过这种途径首先从碳骨架上去除的。赖氨酸通过两种交替的途径代谢，最终汇聚到α-氨基己二酸。导致α-氨基己二酸中赖氨酸α-氮原子保留的主要途径包括糖精作为α-氨基己二酸的前体，因此在大鼠中与赖氨酸分解代谢相同。该途径被认为是次要途径，包括- pipiolate作为α-氨基己二酸的前体，并导致α-氨基己二酸中fl-赖氨酸的ϵ-nitrogen原子保留。尽管糖精被认为是一种中间的赖氨酸分解，但肌肉注射剂量的很大一部分会随尿液排出。
The metabolism ofd- andl-lysine has been studied in the chicken using both14C and15N labels. In contrast to the rat, the chicken actively metabolizedd-lysine andl-pipecolate. The data indicate thatd-lysine is degraded via conversion to pipecolate, α-aminoadipate, α-ketoadipate, and eventually to CO2. The α-nitrogen atom ofd-lysine is the first one removed from the carbon skeleton by this route.l-Lysine is metabolized by two alternate pathways which converge at α-aminoadipate. The major pathway, which results in the retention of the α-nitrogen atom ofl-lysine in α-aminoadipate, includes saccharopine as a precursor of α-aminoadipate and is thus identical tol-lysine catabolism in rats. The pathway which is indicated to be the minor one includesl-pipecolate as a precursor of α-aminoadipate and results in the retention of the ϵ-nitrogen atom ofl-lysine in α-aminoadipate. Even though saccharopine is indicated to be an intermediate inl-lysine breakdown, a large percentage of an intramuscularly injected dose is excreted unchanged in the urine.