A facile asymmetric synthesis of Δ3-2-Hydroxybakuchiol, Bakuchiol and ent-Bakuchiol
A facile asymmetric synthesis of Δ3-2-Hydroxybakuchiol, Bakuchiol and ent-Bakuchiol
复制标题
α3-2-羟基补骨脂酚、补骨脂酚和 ent-补骨脂酚的简便不对称合成
DOI：
10.1016/j.tet.2013.10.064
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发表时间：
2013-12-16
期刊：
影响因子：
2.1
通讯作者：
Lei, Xinsheng
中科院分区：
文献类型：
--
作者：
Xu, Qian-Qian;Zhao, Qun;Lei, Xinsheng
本文通过一种含手性全碳季碳中心的常见中间体，包括含Evans助剂的α、β不饱和亚胺的立体选择性非共轭烷基化反应、Takai-Utimoto反应、根岸反应和Heck反应，实现了Delta(3)-2-羟基Bakuchiol、Bakuchiol和正-Bakuchiol的不对称合成。(C) 2013 Elsevier Ltd.版权所有。
A facile asymmetric synthesis of Delta(3)-2-Hydroxybakuchiol, Bakuchiol, and ent-Bakuchiol is described through one common intermediate bearing a chiral all-carbon quaternary carbon center, which involves stereoselectively unconjugated alkylation of the alpha,beta-unsaturated imide bearing Evans' auxiliary, Takai-Utimoto reaction, Negishi reaction, and Heck reaction as key steps. (C) 2013 Elsevier Ltd. All rights reserved.