The importance of stretch and contractile activity in the prevention of connective tissue accumulation in muscle.
The importance of stretch and contractile activity in the prevention of connective tissue accumulation in muscle.
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DOI：
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发表时间：
1988-06
影响因子：
2.4
通讯作者：
P. Williams;Tony CATANESEt;Edgar G. LUCEYt;G. Goldspink
中科院分区：
文献类型：
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作者：
P. Williams;Tony CATANESEt;Edgar G. LUCEYt;G. Goldspink
当肌肉以缩短的位置固定时，会导致连续肌节的损失，并伴有胶原蛋白比例的增加和肌肉僵硬度的增加。为了确定是否缺乏拉伸或缺乏收缩活动，这是涉及这些变化的主要因素，使用固定和电刺激的不同组合进行实验。研究发现，在不活动的肌肉中发生的结缔组织积聚可以通过被动拉伸或主动刺激来防止。研究还表明，在工作范围缩小的肌肉中，如在缩短位置固定的肌肉中，连续肌节减少。然而，在这种情况下，结缔组织没有伴随增加，再次表明收缩活动对于维持正常肌肉顺应性是重要的。
The loss of serial sarcomeres which results when muscles are immobilised in a shortened position is accompanied by an increase in the proportion of collagen and an increased muscle stiffness. In order to determine whether it is lack of stretch or lack of contractile activity which is the main factor involved in these changes experiments were carried out using different combinations of immobilisation and electrical stimulation. It was found that the connective tissue accumulation that occurs in inactive muscles can be prevented either by passive stretch or by active stimulation. It was also shown that in muscle that is working over a reduced range there is, as in muscle immobilised in the shortened position, a reduction in serial sarcomeres. In this case, however, there is no concomitant increase in connective tissue, again indicating that contractile activity is important for the maintenance of normal muscle compliance.