Hypertension and the brain: Vulnerability of the prefrontal regions and executive functions
Hypertension and the brain: Vulnerability of the prefrontal regions and executive functions
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DOI：
10.1037/0735-7044.117.6.1169
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Acker, JD
中科院分区：
文献类型：
--
作者：
Raz, N;Rodrigue, KM;Acker, JD
未经治疗的高血压会对大脑解剖结构和认知功能产生负面影响，但药物治疗高血压的影响尚不清楚。作者将40名被诊断患有原发性高血压的中年和老年人与人口统计学上匹配的血压正常的同龄人进行了比较。在磁共振成像扫描上测量了7个脑区的宽度和深部及脑室周围白质高信号（WMH）。评估了4个认知领域（持续、工作记忆、流体推理和词汇知识）的表现。高血压患者的前额叶皮质和基础白色物质体积较小，额叶WMH增加。在其他检查的大脑区域中没有发现组间差异。在检查的认知变量中，高血压患者犯下的持续性错误明显更多。因此，即使控制高血压也可能与大脑结构和认知缺陷有关，需要进一步研究。
Untreated hypertension negatively affects brain anatomy and cognitive functions, but the effects of medically treated hypertension are unclear. The authors compared 40 middle-age and older adults diagnosed with essential hypertension to demographically matched normotensive peers. Volumes of 7 brain regions and deep and periventricular white-matter hyperintensities (WMH) were measured on magnetic resonance imaging scans. Performance in 4 cognitive domains (perseveration, working memory, fluid reasoning, and vocabulary knowledge) was evaluated. Persons with hypertension had smaller prefrontal cortex and underlying white matter volumes and increased frontal WMH. No group differences were found in other examined brain regions. Among examined cognitive variables, hypertensive patients committed significantly more perseverative errors. Thus, even controlled hypertension may be associated with deficits in brain structure and cognition, warranting further study.