Negative genetic correlation for adult fitness between sexes reveals ontogenetic conflict in Drosophila
Negative genetic correlation for adult fitness between sexes reveals ontogenetic conflict in Drosophila
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DOI：
10.1073/pnas.041378098
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发表时间：
2001-02-13
影响因子：
11.1
通讯作者：
Rice, WR
中科院分区：
文献类型：
--
作者：
Chippindale, AK;Gibson, JR;Rice, WR
由于雌性和雄性在生殖过程中的不同作用，它们被选择向不同的最佳表型，当同源性状被选择向不同的方向时，两性之间的个体发生冲突就产生了。性别限制基因表达导致的两性异形的进化说明了这个问题。然而，由于大多数基因没有性别限制，因此可能仍然存在实质性冲突的可能性。在这里，我们通过克隆40个单倍体基因组并测量它们在两性中的达尔文适应度来评估果蝇（Drosophila melanogaster）的个体发生冲突的程度。少年生存能力，成年生殖成功，总健身的性间遗传相关性被用来衡量在发展过程中的潜在冲突。首先，作为青少年，其中的健身目标的两性似乎是相似的，生存强烈的正相关性，跨性别。成年后，性别角色分化，生殖成功的显着负相关，最后，由于平衡的相关性在少年和成年的组件，没有发现总适合度的性间相关，高度显着的基因型-性别交互作用方差测量成年和总适合度。这些结果表明，由于性拮抗变异的表达，在发育过程中强烈的性间不和谐。
Because of their distinctive roles in reproduction, females and males are selected toward different optimal phenotypes, Ontogenetic conflict between the sexes arises when homologous traits are selected in different directions. The evolution of sexual dimorphism by sex-limited gene expression alleviates this problem. However, because the majority of genes are not sex-limited, the potential for substantial conflict may remain. Here we assess the degree of ontogenetic conflict in the fruit-fly, Drosophila melanogaster, by cloning 40 haploid genomes and measuring their Darwinian fitness in both sexes. The intersexual genetic correlations for juvenile viability, adult reproductive success, and total fitness were used to gauge potential conflict during development. First, as juveniles, where the fitness objectives of the two sexes appear to be similar, survival was strongly positively correlated across sexes. second, after adult maturation, where gender roles diverge, a significant negative correlation for reproductive success was found. Finally, because of counterbalancing correlations in the juvenile and adult components, no intersexual correlation for total fitness was found. Highly significant genotype-by-gender interaction variance was measured for both adult and total fitness. These results demonstrate strong intersexual discord during development because of the expression of sexually antagonistic variation.