Plant-based oral vaccines: results of human trials.
Plant-based oral vaccines: results of human trials.
复制标题
植物性口服疫苗：人体试验结果。
DOI：
10.1007/978-3-540-70868-1_6
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发表时间：
2009
影响因子：
--
通讯作者：
Tacket,CO
中科院分区：
文献类型：
--
作者：
Tacket,CO
由转基因植物来源的抗原组成的疫苗为开发安全、廉价的疫苗提供了新的策略。疫苗抗原可以与植物的可食用部分一起食用或从植物材料中纯化。在基于马铃薯和玉米的原型疫苗的1期临床研究中，这些疫苗是安全的和免疫原性的，不需要除植物细胞之外的缓冲液或媒介物。转基因植物技术对于疫苗开发是有吸引力的，因为这些疫苗是无针的，稳定的，并且易于管理。本章回顾了一些早期的人类口服转基因植物源性疫苗的研究，这些疫苗可以预防大肠杆菌感染、诺如病毒和B型肝炎。
Vaccines consisting of transgenic plant-derived antigens offer a new strategy for development of safe, inexpensive vaccines. The vaccine antigens can be eaten with the edible part of the plant or purified from plant material. In phase 1 clinical studies of prototype potato- and corn-based vaccines, these vaccines have been safe and immunogenic without the need for a buffer or vehicle other than the plant cell. Transgenic plant technology is attractive for vaccine development because these vaccines are needle-less, stable, and easy to administer. This chapter examines some early human studies of oral transgenic plant-derived vaccines against enterotoxigenicEscherichia coliinfection, norovirus, and hepatitis B.