Oxidative Status and Plasma Lipid Profile in β-Thalassemia Patients
Oxidative Status and Plasma Lipid Profile in β-Thalassemia Patients
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DOI：
10.3109/03630269.2014.979997
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发表时间：
2015-01-01
期刊：
影响因子：
1
通讯作者：
Djerdjouri, Bahia
中科院分区：
文献类型：
--
作者：
Boudrahem-Addour, Nassima;Izem-Meziane, Malika;Djerdjouri, Bahia
β地中海贫血是一种遗传性疾病，是阿尔及利亚的一个主要健康问题。它与脂质水平改变和氧化应激状态有关，可导致心脏并发症和过早死亡。我们检查了46例重型β地中海贫血（β-TM）和中间型β地中海贫血（β-TI）患者的血脂谱和氧化还原状态，并与36例健康受试者进行了比较。检测血脂水平，包括总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。通过测定丙二醛（MDA）、还原型谷胱甘肽（GSH）和过氧化氢酶（CAT）活性来评价氧化状态。这些参数与血红蛋白（Hb）血液浓度，血清铁蛋白，输血的持续时间和频率，脾切除术以及年龄之间的潜在关系进行了检查。我们的数据表明，研究患者处于与高胆固醇血症和低胆固醇血症相关的氧化应激状态增加。CAT活性与Hb浓度、LDL-C/TG比值呈负相关，与输血年限呈正相关。TC/HDL-C比值升高，尤其是在年轻的β-TM患者中，与铁蛋白血症和甘油三酯水平呈正相关，并提示冠状动脉风险增加。这种高风险状态应导致将该指数（TC/HDL-C）纳入临床管理，特别是在脾切除患者中。
beta-Thalassemia (beta-thal) is a genetic disorder, representing a major health problem in Algeria. It is associated with altered lipid levels and a state of oxidative stress that can lead to cardiac complications and premature death. We examined the plasma lipid profile and redox status of 46 patients with beta-thal major (beta-TM) and beta-thal intermedia (beta-TI) compared to 36 healthy subjects. Plasma lipids including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were investigated. Oxidative status was evaluated by measuring malondialdehyde (MDA), reduced glutathione (GSH) and catalase (CAT) activity. The potential relationships between these parameters and the hemoglobin (Hb) blood concentrations, serum ferritin, duration and frequency of transfusion, splenectomy as well as age, were examined. Our data indicated that the study patients were under increased state of oxidative stress associated with hypertriglyceridemia, and hypocholesterolemia. The CAT activity was negatively correlated with Hb concentration and LDL-C/TG ratio and positively with years of transfusion. The elevated TC/HDL-C ratio particularly in beta-TM patients who were younger, correlated positively with ferritinemia and triglyceride levels and suggested an increased coronary risk. This heightened risk state should lead to the inclusion of this index (TC/HDL-C) in clinical management, particularly in splenectomized patients.