Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices
Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices
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DOI：
10.1007/s00417-014-2640-4
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发表时间：
2014-06-01
影响因子：
2.7
通讯作者：
Neubauer, Aljoscha S.
中科院分区：
文献类型：
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作者：
Reznicek, Lukas;Klein, Thomas;Neubauer, Aljoscha S.
目的比较基于超兆赫扫频源傅立叶域模式锁定(FDML)OCT的眼底广角断层图像和重建图像的图像质量，并与当代诊断设备进行比较。使用该设备对12只正常眼睛进行成像，采用各向同性密度采样方案(1,900×1,900 A扫描)，填充系数为100%。将所获得的OCT扫描图像质量与两种商用OCT系统(Heidelberg Spectralis和Stratus OCT)进行比较。结果与彩色眼底、红外和超广域激光扫描图像相比较，15倍平均图像在1.68MHz处具有较高的整体图像质量[总体质量评分：8.42+/-0.52，范围0(差)~10(优)]，与目前的光谱域OCT(总体质量评分：8.83+/-0.39，p=0.731)相当。在FDML OCT上，获得了覆盖中央和中外围视网膜的密集3D数据集。从血管、视盘等视网膜结构判断，重建的FDML OCT眼底图像具有与扫描激光眼底镜(SLO)相当的图像质量。总评分为8.36+/-0.51和8.27+/-0.65(p=0.717)。结论1.68MHz超广域兆赫3DFDML OCT是可行的，其断层图像质量可与现有的光谱域OCT设备相媲美。此外，与目前可用的眼底成像设备相比，重建的眼底图像的面部可视化产生了具有高图像质量的大视野。与商用光谱域OCT技术相比，>；30倍的成像速度提高使高密度扫描协议成为可能，从而为后部节段的高质量横断面和面部图像提供数据集。
Background To investigate the image quality of wide-angle cross-sectional and reconstructed fundus images based on ultra-megahertz swept-source Fourier domain mode locking (FDML) OCT compared to current generation diagnostic devices.Methods A 1,050 nm swept-source FDML OCT system was constructed running at 1.68 MHz A-scan rate covering approximately 70 degrees field of view. Twelve normal eyes were imaged with the device applying an isotropically dense sampling protocol (1,900x1,900 A-scans) with a fill factor of 100 %. Obtained OCT scan image quality was compared with two commercial OCT systems (Heidelberg Spectralis and Stratus OCT) of the same 12 eyes. Reconstructed en-face fundus images from the same FDML-OCT data set were compared to color fundus, infrared and ultra-wide-field scanning laser images (SLO).Results Comparison of cross-sectional scans showed a high overall image quality of the 15x averaged FDML images at 1.68 MHz [overall quality grading score: 8.42 +/- 0.52, range 0 (bad)-10 (excellent)] comparable to current spectral-domain OCTs (overall quality grading score: 8.83 +/- 0.39, p=0.731). On FDML OCT, a dense 3D data set was obtained covering also the central and mid-peripheral retina. The reconstructed FDML OCT en-face fundus images had high image quality comparable to scanning laser ophthalmoscope (SLO) as judged from retinal structures such as vessels and optic disc. Overall grading score was 8.36 +/- 0.51 for FDML OCT vs 8.27 +/- 0.65 for SLO (p=0.717).Conclusions Ultra-wide-field megahertz 3D FDML OCT at 1.68 MHz is feasible, and provides cross-sectional image quality comparable to current spectral-domain OCT devices. In addition, reconstructed en-face visualization of fundus images result in a wide-field view with high image quality as compared to currently available fundus imaging devices. The improvement of >30x in imaging speed over commercial spectral-domain OCT technology enables high-density scan protocols leading to a data set for high quality cross-sectional and en-face images of the posterior segment.