Retinopathy and visual impairment in diabetes, impaired glucose tolerance and normal glucose tolerance: the Nord-Trondelag Health Study (the HUNT study)
Retinopathy and visual impairment in diabetes, impaired glucose tolerance and normal glucose tolerance: the Nord-Trondelag Health Study (the HUNT study)
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DOI：
10.1111/j.1755-3768.2010.01998.x
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发表时间：
2012-05-01
影响因子：
3.4
通讯作者：
Gulbrandsen, Pal
中科院分区：
文献类型：
--
作者：
Sundling, Vibeke;Platou, Carl G. P.;Gulbrandsen, Pal
目的：本研究的目的是描述 HUNT 研究亚人群中视力障碍和视网膜病变的患病率，并调查糖尿病患者、筛查检测出的糖尿病、糖耐量受损和糖耐量正常患者视网膜病变的危险因素。方法：我们使用了 2004 年至 2005 年在挪威 Verdal 进行的一项基于人群的高血糖筛查调查的样本 (n = 163)。基线信息可通过第二次 Nord-Trondelag 健康研究 (HUNT2)（199597）获得。数据收集于 2005 年，包括患者病史、屈光度、视力、白内障评估和单视野、免散瞳视网膜摄影。视网膜照片由两名不了解患者信息的评分者独立评分。使用标准统计方法分析数据，p<0.05被认为是显着的。结果：共有 126 人（77%）参与，其中 55% 是女性。平均 (SD) 年龄为 59 (+/-14) 岁。四人（3%）有可矫正的视力障碍，但没有人患有视力障碍。 109 名 (87%) 参与者的双眼视网膜照片均可分级。已知糖尿病患者的视网膜病变患病率为 11%，筛查检测出糖尿病的患者为 4%，糖耐量受损者为 3%，糖耐量正常者为 10%。视网膜病变与已知的糖尿病史或当前的血糖状况无关。非空腹血糖（199597 年）是视网膜病变的独立危险因素（2005 年），OR (95% CI) 1.5 (1.01, 2.13)，p = 0.046。结论：本研究中糖尿病患者糖尿病视网膜病变的患病率较低。适当的光学矫正和定期眼科检查可以防止糖尿病患者和非糖尿病患者出现不必要的视力障碍。
Purpose: The aim of the study was to describe the prevalence of visual impairment and retinopathy and to investigate risk factors for retinopathy in persons with diabetes, screen-detected diabetes, impaired glucose tolerance and normal glucose tolerance in a subpopulation of the HUNT study. Methods: We used a sample (n = 163) from a population-based screening survey of hyperglycaemia, undertaken in 2004-2005 in Verdal, Norway. Baseline information was accessible through the second Nord-Trondelag Health Study (HUNT2), 199597. Data collection was made in 2005 and included patient history, refraction, visual acuity, cataract assessment and single-field, nonmydriatic retinal photography. Retinal photographs were graded independently by two graders blinded to patient information. Data were analysed with standard statistical methods, and p < 0.05 was considered significant. Results: In all, 126 (77%) persons participated, 55% were women. The mean (SD) age was 59 (+/-14) years. Four (3%) had correctable visual impairment, and none were visually impaired. Retinal photographs were gradable for both eyes in 109 (87%) participants. The prevalence of retinopathy was 11% in persons with known diabetes, 4% in persons with screen-detected diabetes, 3% in persons with impaired glucose tolerance and 10% in persons with normal glucose tolerance. Retinopathy was not associated with known history of diabetes or current glycaemic status. Nonfasting plasma glucose (in 199597) was an independent risk factor for retinopathy (in 2005), OR (95% CI) 1.5 (1.01, 2.13), p = 0.046. Conclusion: The prevalence of diabetic retinopathy in persons with diabetes in this study was low. Appropriate optical correction and regular eye examination can prevent unnecessary visual impairment in both persons with and without diabetes.