Epistasis between mutations is host-dependent for an RNA virus
Epistasis between mutations is host-dependent for an RNA virus
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DOI：
10.1098/rsbl.2012.0396
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发表时间：
2013-02-23
期刊：
影响因子：
3.3
通讯作者：
Elena, Santiago F.
中科院分区：
文献类型：
--
作者：
Lalic, Jasna;Elena, Santiago F.
环境如何以及在多大程度上影响突变相互作用的方式？环境变化会影响上位性的符号和程度吗？在上位性的变异性、符号或大小方面，环境之间是否有任何相关性？很少有研究涉及这些问题。在这里，我们在病毒出现的背景下解决它们。大多数新出现的病毒是RNA病毒，具有小的基因组、重叠的阅读框架和多功能蛋白质，其上位性丰富。了解宿主物种对上位性的影响，将有助于深入了解传染病的进化生态学和病毒出现的可预测性。
How, and to what extent, does the environment influence the way mutations interact? Do environmental changes affect both the sign and the magnitude of epistasis? Are there any correlations between environments in the variability, sign or magnitude of epistasis? Very few studies have tackled these questions. Here, we addressed them in the context of viral emergence. Most emerging viruses are RNA viruses with small genomes, overlapping reading frames and multifunctional proteins for which epistasis is abundant. Understanding the effect of host species in the sign and magnitude of epistasis will provide insights into the evolutionary ecology of infectious diseases and the predictability of viral emergence.