Age-related changes in fibre composition of the human corpus callosum: Sex differences
Age-related changes in fibre composition of the human corpus callosum: Sex differences
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DOI：
10.1097/00001756-199607290-00013
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发表时间：
1996-07-29
期刊：
影响因子：
1.7
通讯作者：
Zaidel, E
中科院分区：
文献类型：
--
作者：
Aboitiz, F;Rodriguez, E;Zaidel, E
我们发现人类有髓鞘胼胝体纤维的数量与年龄呈正相关。直径在1 ~ 3 μ m之间的相对丰富的轴突仅在女性中与年龄相关，而直径在0 ~ 3 μ m之间的纤维稀少仅在男性中与年龄显著相关。在对不同胼胝体节段进行分析时发现，在雌性的身体中部（而不是在脾脏），纤维的数量也随着年龄的增长而增加。在雄性中，这些大直径纤维与年龄的关系在胼胝体分成不同的部分后消失。因此，胼胝体皮层的形成过程可能存在性别差异；正常寿命期间的再生和髓鞘形成。
WE found positive correlations between the number of myelinated callosal fibres > 1 mu m in diameter and age in humans. The relatively abundant axons with diameters between 1 and 3 mu m correlated with age only in females, while the scarce fibres > 3 mu m in diameter correlated significantly with age only in males. When analysing different callosal segments, it was found that in the midbody (but not in the splenium) of females the number of fibres > 3 mu m also increased with age. In males, the relationship between these large diameter fibres and age disappeared after dividing the callosum into distinct segments. There may, therefore, be sex differences in the course of callosal fil;re growth and myelination during the normal lifespan.