Diffusion-weighted MR imaging in assessing cervical tumour response to nonsurgical therapy
Diffusion-weighted MR imaging in assessing cervical tumour response to nonsurgical therapy
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DOI：
10.1007/s11547-011-0650-4
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发表时间：
2011-08-01
影响因子：
8.9
通讯作者：
Bellomi, M.
中科院分区：
文献类型：
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作者：
Rizzo, S.;Summers, P.;Bellomi, M.
本研究旨在评估宫颈肿瘤对非手术治疗（化疗和/或放疗）的反应与表观扩散系数（ADC）值之间是否存在相关性。17例连续患者前瞻性地接受了盆腔磁共振（MR）成像，包括非手术治疗前后的扩散加权成像（DWI）序列。对照组由17名无宫颈病变的患者组成，与研究组相匹配。治疗前后两组间及研究组内基线ADC图的差异通过非参数检验进行评估。治疗后14/17个病灶（应答者）宫颈癌的直径和体积减小，3/17个病灶（无应答者）增加。应答者的ADC值显著增加（p=0.0009）。治疗前后ADC值的百分比变化在应答者中高于无应答者（p=0.04）。在分期MR检查中，应答者和非应答者之间的ADC值无显著差异（p=0.09），治疗前ADC值与肿瘤缩小百分比之间无显著相关性。具有较高百分比ADC值增加的肿瘤显示出较高的肿瘤缩小体积，但这并不显著（p=0.12）治疗后宫颈癌的ADC值与治疗前值相比显示出显著差异，特别是对于应答者。
This study was undertaken to assess whether there is a correlation between the response of cervical tumours to nonsurgical therapy (chemo- and/or radiotherapy) and apparent diffusion coefficient (ADC) values.Seventeen consecutive patients prospectively underwent pelvic magnetic resonance (MR) imaging including diffusion-weighted imaging (DWI) sequences before and after nonsurgical therapy for cervical cancer. A control group of 17 patients without cervical pathology was matched to the study group. Differences in baseline ADC maps between the two groups and within the study group before and after therapy were assessed by nonparametric tests.The diameter and volume of cervical cancers decreased after therapy in 14/17 lesions (responders) and increased in 3/17 lesions (nonresponders). The ADC values of responders increased significantly (p=0.0009). Percent changes in ADC values before and after therapy were higher in responders than nonresponders (p=0.04). There was no significant difference in ADC values between responders and nonresponders at the staging MR examination (p=0.09) and no significant correlation between pretreatment ADC values and percentage of tumour reduction. Tumours with higher percent ADC value increase showed higher tumour reduction volume, but this was not significant (p=0.12).ADC values of cervical cancer after therapy showed significant differences compared with pretherapy values, particularly for responders.