Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants.
Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants.
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DOI：
10.2147/jir.s366336
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发表时间：
2022
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
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空气污染物暴露和新生儿黄疸（NJ）对儿童哮喘有已知的影响，但较高的血清总胆红素（TSB）水平与肺保护有关。本研究旨在评估出生前/出生后暴露于环境空气污染物是否与NJ婴儿哮喘的发生有关。本研究采巢式病例对照回顾性研究，以高雄医学大学医院研究资料库中之新生儿病例为研究对象。收集了六个月内、出生后第一年和第二年以及产前第一、第二和第三个三个月的平均环境空气污染浓度数据。NJ定义为TSB水平≥ 2 mg/dl，诊断时间小于1个月。哮喘被定义为使用药物的诊断。我们构建了条件逻辑回归模型来估计调整后的比值比（aOR）和95%置信区间（CI）。在研究的所有六个时间点暴露于NO和SO2与NJ婴儿的学龄前哮喘风险增加显著相关。SO2、PM2.5、PM10、NO、NO2和NOX的总体峰值OR（95%CI）为1.277（1.129-1.444）、1.057（1.023-1.092）、1.035（1.011-1.059）、1.272（1.111-1.455）、1.168（1.083-1.259）和1.104（1.051-1.161）。妊娠早期和中期的胎儿最容易受到环境空气污染物暴露，如SO2 PM2.5，NO，NO2和NOX在产前期间。在出生后的第一年和第二年暴露于所有六种环境空气污染物对新泽西州婴儿的学龄前哮喘有显着影响。在不同的时间窗，出生前和出生后暴露于SO2，PM2.5，PM10，NO，NO2和NOX与学龄前哮喘的NJ婴儿。NO和SO2暴露对NJ婴儿的影响相对较高，需要进一步研究和预防措施。
Both air pollutant exposure and neonatal jaundice (NJ) have known effects on childhood asthma, but a higher total serum bilirubin (TSB) level has been associated with lung protection. This study aimed to assess whether prenatal/postnatal exposure to ambient air pollutants is related to the development of asthma in infants with NJ. A nested case–control retrospective study was performed using the data of infants with NJ in the Kaohsiung Medical University Hospital Research Database. Data on average ambient air pollution concentrations within six months, the first year and second year after birth, and in the first, second and third prenatal trimesters were collected. NJ was defined as TSB levels ≥ 2 mg/dl with the diagnosis less than one-month-old. Asthma was defined as a diagnosis with medication use. We constructed conditional logistic regression models to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Exposure to NO and SO2 at all six time points in the study was significantly associated with an increased risk of preschool asthma in infants with NJ. The overall peak OR (95% CI) of SO2, PM2.5, PM10, NO, NO2, and NOX were 1.277 (1.129–1.444), 1.057 (1.023–1.092), 1.035 (1.011–1.059), 1.272 (1.111–1.455), 1.168 (1.083–1.259) and 1.104 (1.051–1.161), respectively. Fetuses in the first and second trimester were most vulnerable to ambient air pollutant exposure such as SO2 PM2.5, NO, NO2 and NOX during the prenatal period. Exposure to all six ambient air pollutants during the first and second years after birth significantly affected preschool asthma in NJ infants. In different time windows, prenatal and postnatal exposure to SO2, PM2.5, PM10, NO, NO2, and NOX were associated with preschool asthma in NJ infants. The relatively high impact of NO and SO2 exposure in infants with NJ requires further studies and prevention measures.