MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain.
MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain.
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DOI：
10.1177/2058460115609635
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发表时间：
2015-11
影响因子：
1.1
通讯作者：
Ringstad G
中科院分区：
文献类型：
--
作者：
Eide PK;Ringstad G
最近，在啮齿动物中发现了脑的“胶质淋巴系统”，其是用于清除过量脑代谢物和化合物在脑脊液中分布的血管旁、脑实质途径。已经证明鞘内注射钆（Gd）造影剂在大鼠中沿着沿着这一途径分布，但迄今为止在人体中还没有。1例27岁女性患者鞘内注射钆布醇进行磁共振成像（MRI），1小时和4.5小时后钆布醇分布于整个大脑。鞘内注射Gd的MRI可能成为研究人脑胶质淋巴功能的工具。
Recently, the “glymphatic system” of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5 h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.