Metalloproteinases in tumor progression: the contribution of MMP-9.
Metalloproteinases in tumor progression: the contribution of MMP-9.
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发表时间：
1994
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通讯作者：
B. Himelstein;R. Cañete‐soler;E. Bernhard;Dilks Dw;R. Muschel
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作者：
B. Himelstein;R. Cañete‐soler;E. Bernhard;Dilks Dw;R. Muschel
许多能够降解细胞外基质和基底膜的蛋白水解酶与肿瘤进展有关，包括基质金属蛋白酶、组织蛋白酶、纤溶酶原激活剂和肝素酶。基质金属蛋白酶是一类依赖锌的蛋白酶，参与肿瘤进展的几个步骤，包括侵袭、转移和血管生成。在这篇综述中，我们将简要概述该蛋白酶家族，并将回顾一种特殊的金属蛋白酶，92-kD型IV型胶原酶/明胶酶（MMP-9或明胶酶B）以及其他金属蛋白酶在癌症进展中的体外和体内证据。最后，利用我们实验室最近的研究，我们将证明肿瘤细胞和宿主基质细胞产生MMP-9在肿瘤进展中的重要性。
Many enzymes capable of proteolytic degradation of extracellular matrix and basement membranes have been implicated in tumor progression, including the matrix metalloproteinases, cathepsins, plasminogen activators, and heparanase. Matrix metalloproteinases, a family of zinc-dependent proteases, participate in several steps in tumor progression, including invasion, metastasis, and angiogenesis. In this review, we will give a brief overview of this protease family, and we will review in vitro and in vivo evidence implicating a particular metalloproteinase, the 92-kD type IV collagenase/gelatinase (MMP-9 or gelatinase B), as well as other metalloproteinases, in cancer progression. Finally, using recent studies from our laboratory, we will demonstrate the importance of both tumor cell and host stromal cell production of MMP-9 in tumor progression.