Could Exercise Metabolomics Pave the Way for Gymnomimetics?
Could Exercise Metabolomics Pave the Way for Gymnomimetics?
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DOI：
10.1126/scitranslmed.3001188
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发表时间：
2010-07-21
影响因子：
17.1
通讯作者：
Rader, Daniel J.
中科院分区：
文献类型：
--
作者：
Burke, Megan F.;Dunbar, Richard L.;Rader, Daniel J.
有规律的身体活动，特别是有氧运动与降低疾病风险和延长寿命有关，但这些健康益处的分子机制仍然不清楚。一种综合的代谢组学方法被用来表征剧烈运动后>200种代谢物的血液水平的变化，并确定了24种发生了实质性变化。一种是烟酰胺，它与烟酰胺腺嘌呤二核苷酸（NAD+）及其还原形式NADH的代谢密切相关，而后者又与运动能力和健康状况有关。对运动引起的代谢变化的深入研究可能会导致药理学尝试模拟运动的有益作用，我们称之为“拟体操”。"
Regular physical activity and especially aerobic exercise are associated with reduced risk of disease and enhanced longevity, but the molecular mechanisms of these health benefits remain obscure. A comprehensive metabolomic approach was used to characterize the changes in blood levels of >200 metabolites upon vigorous exercise and identified two dozen that changed substantially. One, niacinamide, is intimately related to the metabolism of nicotinamide adenine dinucleotide (NAD+) and its reduced form NADH, which is in turn linked with exercise capacity as well as health status. Intensive investigation of metabolic changes with exercise could lead to pharmacological attempts to mimic the beneficial effects of exercise, an approach we term "gymnomimetics."