EFFECT OF PANTOTHENIC ACID ON GROWTH AND BLOOD PICTURE IN THE RAT
EFFECT OF PANTOTHENIC ACID ON GROWTH AND BLOOD PICTURE IN THE RAT
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DOI：
10.1079/bjn19570013
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发表时间：
1957-01-01
影响因子：
3.6
通讯作者：
COPPING, AM
中科院分区：
文献类型：
--
作者：
BLUNT, AD;CHEESMAN, EM;COPPING, AM
从断奶开始，用补充了足量除泛酸外的所有已知维生素的纯化饲料喂养带帽大鼠（101）。从试验开始或剥夺2周后，每天向各组给予25、50或100 [mu]g泛酸，并将反应与未给药的对照组进行比较。雄性大鼠对泛酸的生长反应似乎比雌性大鼠更敏感，但一般而言，在3个剂量水平处理中观察到的生长反应分级非常小。每日剂量为25 [mu]g的泛酸几乎足以促进生长。但不能完全防止黑色皮毛变灰。大鼠剥夺泛酸表现出显着增加红细胞计数和小细胞和低色素红细胞。
Hooded rats (101) were fed from weaning on a purified diet supplemented with adequate amounts of all known vitamins except pantothenic acid. Groups were dosed daily with 25, 50 or 100 [mu]g pantothenic acid, either from the beginning of the test or after 2 weeks deprivation, and responses were compared with undosed controls. Male rats appeared more sensitive than females in their growth response to pantothenlc acid, however in general very little gradation in growth response was noted among the 3 dosage level treatments. A daily dose of 25 [mu]g pantothenic acid was almost adequate for growth. but did not completely prevent greying of the black fur. Rats deprived of pantothenic acid showed significantly increased red cell counts and microcytic and hypochromic red cells.