Injury- and use-related plasticity in adult auditory cortex
Injury- and use-related plasticity in adult auditory cortex
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DOI：
10.1159/000046831
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发表时间：
2001-07-01
影响因子：
1.6
通讯作者：
Brown, M
中科院分区：
文献类型：
--
作者：
Irvine, DRF;Rajan, R;Brown, M
在成年动物耳蜗局灶性损伤后，皮层区域神经元的频率选择性发生改变，被病变剥夺了其正常输入，以致该区域被邻近(周边)频率的扩展表示占据。这些变化反映了一个动态的重组(可塑性)过程，并不能解释为病变的被动后果。在增强特定声音刺激的重要性的行为训练之后，可以看到皮质频率选择性和组织性的类似可塑性。与损伤和使用相关的听觉皮质可塑性的发生引发了许多问题，涉及的机制，这种可塑性变化的知觉后果和功能意义，以及它们对假体设备输入的中央处理的影响。本文简要总结了与这些问题相关的证据，并对未来的研究方向进行了展望。版权所有(C)2001 S.Karger AG，巴塞尔。
After restricted cochlear lesions in adult animals the frequency selectivity of neurons in the cortical region deprived of its normal input by the lesion is changed such that the region is occupied by expanded representations of adjacent (perilesion) frequencies. These changes reflect a dynamic process of reorganization (plasticity) and are not explicable as passive consequences of the lesion. Analogous plasticity of cortical frequency selectivity and organization is seen following behavioural training that enhances the significance of particular acoustic stimuli. The occurrence of injury- and use-related auditory cortical plasticity gives rise to a number of questions relating to the mechanisms involved, the perceptual consequences and functional significance of such plastic changes, and their implications for the central processing of input from prosthetic devices. Evidence relating to these issues is briefly summarized in this review, and the directions of future research are considered. Copyright (C) 2001 S. Karger AG, Basel.