Oscillatory and intrinsic membrane properties of guinea pig nucleus prepositus hypoglossi neurons in vitro.
Oscillatory and intrinsic membrane properties of guinea pig nucleus prepositus hypoglossi neurons in vitro.
复制标题
体外豚鼠舌下核前核神经元的振荡和内在膜特性。
DOI：
10.1152/jn.01355.2005
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发表时间：
2006
影响因子：
2.5
通讯作者：
L. Moore
中科院分区：
文献类型：
--
作者：
E. Idoux;M. Serafin;P. Fort;P. Vidal;M. Beraneck;N. Vibert;M. Mühlethaler;L. Moore
位于前置舌下核（PHN）的眼神经元整合器的许多模型涉及高度调谐的递归网络和内在的神经元特性;然而，这两种机制的相对作用几乎没有实验证据。本文报道的实验表明，所有的PHN神经元（PHNn）显示出显着的相位行为，这是高度振荡的人口约25%。PHNn的这个子集的行为，被称为D型PHNn，是明显不同的内侧前庭核神经元，其传输大量的头部速度相关的感觉前庭输入，而不整合它们。我们研究了PHNn的放电和生物物理特性，并开发了基于数据的真实神经元模型，以定量地说明它们的活性电导可以产生振荡行为。虽然一些个体D型PHNn能够显示出数学积分的一些特征，但这种行为缺乏鲁棒性强烈表明，可能涉及所有类型的PHNn的额外网络相互作用对于神经元积分器是必不可少的。此外，D型PHNn的脉冲活动和膜电位之间的关系是高度非线性和频率依赖性的，即使是相对较小的振幅响应。这些结果表明，D型PHNn的一些突触输入很可能引起振荡反应，随着尖峰放电率的增加，振荡反应将被非线性放大。看来PHNn具有特定的内在属性，与网络互连相结合，增强了其功能所需的持续神经活动。
Numerous models of the oculomotor neuronal integrator located in the prepositus hypoglossi nucleus (PHN) involve both highly tuned recurrent networks and intrinsic neuronal properties; however, there is little experimental evidence for the relative role of these two mechanisms. The experiments reported here show that all PHN neurons (PHNn) show marked phasic behavior, which is highly oscillatory in approximately 25% of the population. The behavior of this subset of PHNn, referred to as type D PHNn, is clearly different from that of the medial vestibular nucleus neurons, which transmit the bulk of head velocity-related sensory vestibular inputs without integrating them. We have investigated the firing and biophysical properties of PHNn and developed data-based realistic neuronal models to quantitatively illustrate that their active conductances can produce the oscillatory behavior. Although some individual type D PHNn are able to show some features of mathematical integration, the lack of robustness of this behavior strongly suggests that additional network interactions, likely involving all types of PHNn, are essential for the neuronal integrator. Furthermore, the relationship between the impulse activity and membrane potential of type D PHNn is highly nonlinear and frequency-dependent, even for relatively small-amplitude responses. These results suggest that some of the synaptic input to type D PHNn is likely to evoke oscillatory responses that will be nonlinearly amplified as the spike discharge rate increases. It would appear that the PHNn have specific intrinsic properties that, in conjunction with network interconnections, enhance the persistent neural activity needed for their function.
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DOI：
10.1073/pnas.93.24.13481
发表时间：
1996-11-26
影响因子：
11.1
作者：
Marder, E;Abbott, LF;Golowasch, J
通讯作者：
Golowasch, J
来自猫感觉运动皮层的第五层锥体神经元中的两个瞬时钾电流。
DOI：
10.1113/jphysiol.1991.sp018488
发表时间：
1991
期刊：
The Journal of physiology
影响因子：
--
作者：
Spain,WJ;Schwindt,PC;Crill,WE
通讯作者：
Crill,WE
舌下前肌的血清素抑制性突触后电位由两个钾电流介导。
DOI：
10.1523/jneurosci.15-01-00223.1995
发表时间：
1995
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience.
影响因子：
--
作者：
Bobker,DH;Williams,JT
通讯作者：
Williams,JT
影响因子：
2.5
作者：
CANNON, SC;ROBINSON, DA
通讯作者：
ROBINSON, DA
影响因子：
5.5
作者：
BOBKER, DH;WILLIAMS, JT
通讯作者：
WILLIAMS, JT