SYNAPTIC CODE FOR SENSORY MODALITIES REVEALED BY C-ELEGANS GLR-1 GLUTAMATE-RECEPTOR
SYNAPTIC CODE FOR SENSORY MODALITIES REVEALED BY C-ELEGANS GLR-1 GLUTAMATE-RECEPTOR
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DOI：
10.1038/378082a0
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发表时间：
1995-11-02
期刊：
影响因子：
64.8
通讯作者：
KAPLAN, JM
中科院分区：
文献类型：
--
作者：
HART, AC;SIMS, S;KAPLAN, JM
神经系统如何将环境刺激编码为感官体验？刺激的类型（视觉，嗅觉，味觉，机械或听觉）和质量（空间位置，强度或频率）都表示为神经代码。在这里，我们进行了秀丽隐杆线虫的感觉方式编码的遗传分析。ASH感觉神经元对两种不同的感觉刺激（鼻触和渗透刺激）作出反应。glr-1（谷氨酸受体）基因的突变消除了对鼻子触摸的反应，但对渗透性驱避剂没有影响。预测的GLR-1蛋白与哺乳动物AMPA类谷氨酸受体（GluR）亚基大约有40%相同。对glr-1表达和遗传镶嵌的分析表明，GLR-1受体作用于ASH神经元的突触靶点。我们建议，歧视之间的ASH感觉方式产生的差异释放的ASH神经递质响应于不同的刺激。
How does the nervous system encode environmental stimuli as sensory experiences? Both the type (visual, olfactory, gustatory, mechanical or auditory) and the quality of a stimulus (spatial position, intensity or frequency) are represented as a neural code. Here we undertake a genetic analysis of sensory modality coding in Caenorhabditis elegans. The ASH sensory neurons respond to two distinct sensory stimuli (nose touch and osmotic stimuli). A mutation in the glr-1 (glutamate receptor) gene eliminates the response to nose touch but not to osmotic repellents. The predicted GLR-1 protein is roughly 40% identical to mammalian AMPA-class glutamate receptor (GluR) subunits. Analysis of glr-1 expression and genetic mosaics indicates that GLR-1 receptors act in synaptic targets of the ASH neurons. We propose that discrimination between the ASH sensory modalities arises from differential release of ASH neurotransmitters in response to different stimuli.