Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: A review
Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: A review
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DOI：
10.1002/jbt.20412
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发表时间：
2012-02-01
影响因子：
3.6
通讯作者：
Hu, Shen-Jiang
中科院分区：
文献类型：
--
作者：
Chen, Fei;Hu, Shen-Jiang
抑癌基因 p53 可直接调节 microRNA-34a (miR-34a) 的表达。 miR-34a 调节大量靶蛋白，这些蛋白参与细胞周期、凋亡、分化和细胞发育。miR-34a 位于染色体 1p36.23 区域，该区域在许多肿瘤类型中通常被删除，同时导致 miR-34a 表达缺失。因 CpG 甲基化而失活的 miR-34a 基因启动子也会诱导 miR-34a 表达丧失。异位 miR-34a 表达可诱导细胞凋亡、细胞周期停滞和分化或减少迁移。本综述总结了 miR-34a 在细胞周期、分化和凋亡中的作用的进展。 (c) 2011 Wiley periodicals, Inc. J Biochem Mol Toxicol 26:7986 2012；在线查看这篇文章，网址为。 DOI 10.1002/jbt.20412
The tumor suppressor gene p53 was shown to directly regulate the expression of microRNA-34a (miR-34a). miR-34a regulates a plethora of target proteins, which are involved in cell cycle, apoptosis, differentiation, and cellular development.miR-34a resides in the region of chromosome 1p36.23, which is commonly deleted in many tumor types, while it results in the loss expression of miR-34a. The promoters of the miR-34a gene subject to inactivation by CpG methylation also induce the loss expression of miR-34a. Ectopic miR-34a expression induces apoptosis, cell cycle arrest, and differentiation or reduces migration. This review summarizes the progress regarding the role of miR-34a in cell cycle, differentiation, and apoptosis. (c) 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:7986 2012; View this article online at . DOI 10.1002/jbt.20412