Non‐apoptotic cell death in Caenorhabditis elegans
Non‐apoptotic cell death in Caenorhabditis elegans
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DOI：
10.1002/dvdy.22230
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发表时间：
2010-05
影响因子：
2.5
通讯作者：
M. Vlachos;Nektarios Tavernarakis
中科院分区：
文献类型：
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作者：
M. Vlachos;Nektarios Tavernarakis
简单的线虫秀丽隐杆线虫在破译细胞凋亡的分子机制方面发挥了重要作用。除了细胞凋亡之外，线虫中还描述了几种由遗传或外在触发的非凋亡细胞死亡范例。值得注意的是，线虫的非凋亡细胞死亡和人类的病理性细胞死亡有许多共同的关键特征和机制。这些共性表明，与细胞凋亡类似，非细胞凋亡的细胞死亡机制也是保守的，并使线虫成为一种有用的生物体，可以用来建模和剖析人类病理学。事实上，线虫的遗传可塑性和复杂的分子工具对增进我们对非凋亡细胞死亡的理解做出了决定性的贡献。在这里，我们回顾了有关线虫各种类型非凋亡细胞死亡的文献，并讨论了其与人类病理状况相关的影响。发展动力学 239:1337–1351, 2010。© 2010 Wiley‐Liss, Inc.
The simple nematode worm Caenorhabditis elegans has been instrumental in deciphering the molecular mechanisms underlying apoptosis. Beyond apoptosis, several paradigms of non‐apoptotic cell death, either genetically or extrinsically triggered, have also been described in C. elegans. Remarkably, non‐apoptotic cell death in worms and pathological cell death in humans share numerous key features and mechanistic aspects. Such commonalities suggest that similarly to apoptosis, non‐apoptotic cell death mechanisms are also conserved, and render the worm a useful organism, in which to model and dissect human pathologies. Indeed, the genetic malleability and the sophisticated molecular tools available for C. elegans have contributed decisively to advance our understanding of non‐apoptotic cell death. Here, we review the literature on the various types of non‐apoptotic cell death in C. elegans and discuss the implications, relevant to pathological conditions in humans. Developmental Dynamics 239:1337–1351, 2010. © 2010 Wiley‐Liss, Inc.