SCRN1 Is a Novel Marker for Prognosis in Colorectal Cancer
SCRN1 Is a Novel Marker for Prognosis in Colorectal Cancer
复制标题
DOI：
10.1002/jso.21459
复制
发表时间：
2010-02-01
影响因子：
2.5
通讯作者：
Mori, Masaki
中科院分区：
文献类型：
--
作者：
Miyoshi, Norikatsu;Ishii, Hideshi;Mori, Masaki
Secernin 1（SCRN 1）是Secernin家族的一员，是一种肿瘤相关抗原。先前的报告表明，SCRN1是上调胃癌细胞系，可能是一种新的免疫治疗靶点，而其意义在结直肠癌（CRC）是不完全understood. Materials and Methods：本研究包括54例患者接受手术的CRC，以及两个细胞系来自人类CRC。我们评估的相关性的基因表达与临床参数的CRC患者，和敲低进行了评估，在细胞line.Results：30的54例（55.5%）表现出较高的SCRN 1基因的表达在癌区域比边缘非癌区域。SCRN1高表达的患者在统计学上易受不良预后的影响，并且与低表达的患者相比，无病生存率较差。SCRN1在两种细胞系中的敲低表明siRNA抑制导致细胞生长的统计学显著降低。结论：目前的数据强烈表明，SCRN1表达是结直肠癌患者的预后因素。外科肿瘤学杂志2070; 101：156 - 159。(C)2009威利-利斯公司
Purpose: Secernin 1 (SCRN1) is a member of the secernin family and is reported to be a tumor-associated antigen. Previous reports show that SCRN1 is upregulated in gastric cancer cell lines and may be a novel immunotherapy target, whereas its significance in colorectal cancer (CRC) is not fully understood.Materials and Methods: The present study comprised 54 patients who underwent surgery for CRC, as well as two cell lines derived from human CRC. We assessed the correlation of gene expression with clinical parameters in the CRC patients, and knockdown was evaluated in the cell lines.Results: Thirty of the 54 (55.5%) cases exhibited a higher expression of the SCRN1 gene in cancerous regions than marginal non-cancerous regions. Patients with high SCRN1 expression were statistically susceptible to a poor prognosis and showed poorer disease-free survival than those with low expression. SCRN1 knockdown in the two cell lines demonstrated that the siRNA inhibition resulted in a statistically significant reduction in cell growth.Conclusion: The present data strongly suggest that SCRN1 expression is a prognostic factor in CRC patients. J. Surg. Oncol. 2070;101:156-159. (C) 2009 Wiley-Liss, Inc.