TRANSCRIPTIONAL ACTIVATION OF THE ALPHA-1-ACID GLYCOPROTEIN GENE BY YY1 IS MEDIATED BY ITS FUNCTIONAL INTERACTION WITH A NEGATIVE TRANSCRIPTION FACTOR
TRANSCRIPTIONAL ACTIVATION OF THE ALPHA-1-ACID GLYCOPROTEIN GENE BY YY1 IS MEDIATED BY ITS FUNCTIONAL INTERACTION WITH A NEGATIVE TRANSCRIPTION FACTOR
复制标题
DOI：
10.1089/dna.1994.13.1029
复制
发表时间：
1994-10-01
影响因子：
3.1
通讯作者：
LEE, SC
中科院分区：
文献类型：
--
作者：
LEE, YM;LEE, SC
α-1酸性糖蛋白（AGP）基因表达的调控涉及正转录因子和负转录因子。我们以前已经确定了两个主导因素：积极和消极的转录因子，AGP/EBP和B因子，分别参与AGP和其他急性期反应基因的转录。在这份报告中，我们提出的证据表明，AGP基因的转录正调控的转录因子，YY 1。YY 1对AGP基因的激活是由AGP启动子区的负调控元件B介导的。YY 1还可以激活与异源启动子连接的B基序。然而，YY 1本身不直接结合到B基序。相反，我们的数据表明，由YY 1的AGP基因的激活可能是通过其与因子B，它识别的B基序的功能相互作用介导。
Regulation of alpha-1 acid glycoprotein (AGP) gene expression involves both positive and negative transcription factors. We have previously identified two dominant factors: positive and negative transcription factors, AGP/EBP and factor B, respectively, involved in the transcription of AGP and other acute-phase response genes. In this report, we present evidence showing that the transcription of the AGP gene is positively regulated by a transcription factor, YY1. The activation of AGP gene by YY1 is mediated by a negative element B in the AGP promoter region. YY1 can also activate the B motif linked to a heterologous promoter. However, YY1 does not bind directly to the B motif per se. Rather, our data suggest that the activation of AGP gene by YY1 may be mediated by its functional interaction with factor B, which recognizes the B motif.