Effects of sustained interstitial fluid pressurization under migrating contact area, and boundary lubrication by synovial fluid, on cartilage friction
Effects of sustained interstitial fluid pressurization under migrating contact area, and boundary lubrication by synovial fluid, on cartilage friction
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DOI：
10.1016/j.joca.2008.02.020
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发表时间：
2008-10-01
影响因子：
7
通讯作者：
Ateshian, G. A.
中科院分区：
文献类型：
--
作者：
Caligaris, M.;Ateshian, G. A.
目的：本实验研究测试两个假设，解决突出的问题，在软骨润滑：可以保持低摩擦系数在持续的生理负荷条件下？滑液（SF）在润滑关节软骨方面有多有效？基于理论，假设迁移接触区域可以无限期地保持升高的软骨间质液加压，从而保持低摩擦系数。还假设SF干的有益效果来自边界润滑而不是流体膜润滑。设计：对未成熟的牛股骨胫骨关节进行了五个实验，以比较迁移与静止接触区域下的摩擦响应; SF与盐水中的摩擦响应;滑动速度的作用和一致性对摩擦系数的作用。在生理负荷条件下，迁移接触区可保持较低的摩擦系数，持续时间至少为1 h。SF相对于生理盐水将摩擦系数降低了1.5倍。然而，组织间液加压更有效，相对于平衡（零压力）条件，摩擦系数降低了60倍。结论：这些结果强调了间质液加压对软骨摩擦反应的重要性。它们意味着必须保持软骨的机械完整性以在关节中产生低摩擦。SF的有效性更有限，这意味着在退化关节中关节内注射润滑剂对其摩擦学特性的有效性可能有限。(C)2008年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: This experimental study tests two hypotheses which address outstanding questions in cartilage lubrication: can the friction coefficient remain low under sustained physiological loading conditions? How effective is synovial fluid (SF) in the lubrication of articular cartilage? Based on theory, it is hypothesized that migrating contact areas can maintain elevated cartilage interstitial fluid pressurization, thus a low friction coefficient, indefinitely. It is also hypothesized that the beneficial effects of SF stem from boundary lubrication rather than fluid-film lubrication.Design: Five experiments were conducted on immature bovine femoro-tibial joints, to compare the frictional response under migrating vs stationary contact areas; the frictional response in SF vs saline; the role of sliding velocity and the role of congruence on the friction coefficient.Results: Migrating contact area could maintain a low friction coefficient under sustained physiological conditions of loading for at least 1 h. SF reduced the friction coefficient by a factor of similar to 1.5 relative to saline. However, interstitial fluid pressurization was far more effective, reducing the friction coefficient by a factor of similar to 60 relative to equilibrium (zero-pressure) conditions. It was confirmed that SF acts as a boundary lubricant.Conclusions: These results emphasize the importance of interstitial fluid pressurization on the frictional response of cartilage. They imply that the mechanical integrity of cartilage must be maintained to produce low friction in articular joints. The more limited effectiveness of SF implies that intra-articular injections of lubricants in degenerated joints may have only limited effectiveness on their tribological properties. (C) 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.