Mature Pseudomonas aeruginosa Biofilms Prevail Compared to Young Biofilms in the Presence of Ceftazidime
Mature Pseudomonas aeruginosa Biofilms Prevail Compared to Young Biofilms in the Presence of Ceftazidime
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DOI：
10.1128/aac.00650-12
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发表时间：
2012-09-01
影响因子：
4.9
通讯作者：
Saward, Laura L.
中科院分区：
文献类型：
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作者：
Bowler, Laura L.;Zhanel, George G.;Saward, Laura L.
比较了成熟和年轻铜绿假单胞菌PAO 1生物膜和释放的铜绿假单胞菌对4种抗生素的表型耐受性。庆大霉素和环丙沙星的耐药水平相似，但头孢他啶和美罗培南的耐药水平不同。β-内酰胺酶图谱显示，头孢他啶暴露5 h后，成熟生物膜比年轻生物膜产生更多的β-内酰胺酶，促进释放的嗜酸性细菌的生长。这表明早期治疗和选择抗生素对铜绿假单胞菌生物被膜感染的重要性。
Phenotypic tolerances to antibiotics of mature and young Pseudomonas aeruginosa PAO1 biofilms and released planktonic bacteria were compared for four antibiotics. Resistance levels were similar for gentamicin and ciprofloxacin but differed for ceftazidime and meropenem. beta-Lactamase mapping showed that, after 5 h of ceftazidime exposure, mature biofilms produced more beta-lactamase than young biofilms, facilitating the growth of released planktonic bacteria. This shows the importance of early treatment and choice of antibiotics for P. aeruginosa biofilm infections.