Recent developments in computational approaches for uncovering genomic homology
Recent developments in computational approaches for uncovering genomic homology
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DOI：
10.1002/bies.20127
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发表时间：
2004-11-01
期刊：
影响因子：
4
通讯作者：
Van de Peer, Y
中科院分区：
文献类型：
--
作者：
Simillion, C;Vandepoele, K;Van de Peer, Y
在研究基因组进化时，识别基因组内和基因组之间的基因组同源性至关重要。在过去的几年中，已经开发了不同的计算技术来检测同源性，即使同源片段之间的实际相似性很低。根据所使用的策略，这些方法搜索染色体片段对，其中基因内容和顺序都是保守的，或者仅基因内容。然而，由于同源区段在其分歧后可能丢失不同的基因组，因此这些方法仍然常常不能检测基因组同源性。最近，已经开发了更先进的方法，其可以将多个基因组区段的基因顺序和内容信息联合收割机组合。(C)2004 Wiley Periodicals，Inc.
Identifying genomic homology within and between genomes is essential when studying genome evolution. In the past years, different computational techniques have been developed to detect homology even when the actual similarity between homologous segments is low. Depending on the strategy used, these methods search for pairs of chromosomal segments between which either both gene content and order are conserved or gene content only. However, due to fact that, after their divergence, homologous segments can lose a different set of genes, these methods still often fail to detect genomic homology. Recently, more advanced approaches have been developed that can combine gene order and content information of multiple genomic segments. (C) 2004 Wiley Periodicals, Inc.