Development of scalable and versatile nanomaterial libraries for nanosafety studies: polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles
Development of scalable and versatile nanomaterial libraries for nanosafety studies: polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles
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DOI：
10.1039/c6ra25064e
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发表时间：
2017-01-01
期刊：
影响因子：
3.9
通讯作者：
Valsami-Jones, E.
中科院分区：
文献类型：
--
作者：
Briffa, S. M.;Lynch, I.;Valsami-Jones, E.
人造纳米材料 (NM) 的潜在长期环境影响仍然知之甚少，更好地预测 NM 的命运、转变和慢性影响的需要尤为迫切。与散装纳米材料相比，制造的纳米材料具有独特的物理和化学特性，这会影响其行为、稳定性和毒性。因此，有必要为环境纳米科学和纳米（生态）毒理学开发标准和参考 NM 库，并通过定量结构-活性关系等方式促进 NM 命运的计算预测。这项工作的目的是开发并充分表征一个这样的库，其中包括具有一系列核心化学成分的类似 NM，但具有相同的封端剂和尺寸范围，用于未来的研究，以测试核心化学成分是控制毒性的主要因素的假设。该库包含以下 NM：10k、40k 和 360k PVP 封端的二氧化铈、氧化锌和氧化铜（总共 9 个 NM）。这里提出的工作支持了以下假设：NM 形成的机制在所有情况下都是相同的，这表明该协议非常稳健，有可能生成各种可比较的金属氧化物 NM，并有可能通过掺杂金属氧化物和金属 NM 进一步扩展库。通过 DLS（尺寸和 zeta 测量）、UV/Vis、XPS、FT-IR、TEM、STEM、EDX 和 EELS 进行表征，证实所测试的合成方案可以轻松成功地用于创建稳定的 PVP 封端的金属氧化物 NM，其尺寸可重现。
The potential long-term environmental impact of manufactured nanomaterials (NMs) remains poorly understood, and the need to better predict NM fate and transformations and chronic effects is particularly urgent. Compared to their bulk counterparts, manufactured NMs can have distinct physical and chemical characteristics, which influence their behaviour, stability and toxicity. It is therefore essential to develop standard and reference NM libraries for environmental nanoscience and nano(eco) toxicology, and to facilitate a move towards computational prediction of NM fate, through quantitative structure-activity relationships for example. The aim of this work was to develop and fully characterise one such library, which included comparable NMs with a range of core chemistries, but the same capping agent and size range, for use in future studies to test the hypothesis that the core chemistry is a primary factor in controlling toxicity. The library contained the following NMs: 10k, 40k and 360k PVP capped ceria, zinc oxide and copper oxide (9 NMs in total). The work presented here upholds the underpinning hypothesis that the mechanism of NM formation is the same in all cases, suggesting that the protocol is very robust and has the potential to generate a wide range of comparable metal oxide NMs and potentially expand the library further with doped metal oxide and metal NMs. Characterisation by means of DLS (both size and zeta measurements), UV/Vis, XPS, FT-IR, TEM, STEM, EDX and EELS confirms that the tested synthesis protocol can easily and successfully be used to create stable PVP capped metal oxide NMs of reproducible sizes.