Copper-catalyzed arylation of heterocycle C-H bonds
Copper-catalyzed arylation of heterocycle C-H bonds
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DOI：
10.1021/ja075802
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发表时间：
2007-10-17
影响因子：
15
通讯作者：
Daugulis, Olafs
中科院分区：
文献类型：
--
作者：
Do, Hien-Quang;Daugulis, Olafs
发展了一种铜催化的卤代芳烃直接芳基化杂环C-H键的新方法。除了富电子的五元杂环之外，贫电子的吡啶氧化物也可以被芳基化。通过使用叔丁醇锂碱、芳基碘偶联配体和碘化铜催化剂的组合获得最佳结果。
A new method for the direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl halides has been developed. In addition to electron-rich five-membered heterocycles, electron-poor pyridine oxides can also be arylated. The best results are obtained by using a combination of lithium tert -butoxide base, aryl iodide coupling partner, and copper iodide catalyst.