Evidence of three new members of malignant catarrhal fever virus group in muskox (Ovibos moschatus), Nubian ibex (Capra nubiana), and gemsbok (Oryx gazella)
Evidence of three new members of malignant catarrhal fever virus group in muskox (Ovibos moschatus), Nubian ibex (Capra nubiana), and gemsbok (Oryx gazella)
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DOI：
10.7589/0090-3558-39.4.875
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发表时间：
2003-10-01
影响因子：
1.3
通讯作者：
Crawford, TB
中科院分区：
文献类型：
--
作者：
Li, H;Gailbreath, K;Crawford, TB
反刍动物鼻病毒的恶性卡他热（MCF）病毒组的六个成员已被确定。这些病毒中有四种与临床疾病明显相关：由牛羚（Connochaestralspp.）携带的Alcelaphine疱疹病毒I（AlHV-1）;绵羊疱疹病毒2型（OvHV-2），在家养绵羊中普遍存在;山羊疱疹病毒2型（CpHV-2），在家养山羊中流行;以及在白尾鹿（Odocoileus virginianus; MCFV-WTD）中发现的引起经典MCF的未知来源的病毒。使用血清学和聚合酶链反应，靶向部分疱疹病毒DNA聚合酶基因的简并引物，MCF病毒组中的三个以前未被识别的rhadinoviruses的证据被发现在麝牛（Ovibos moschatus），努比亚山羊（Capra nubiana），和gemsbok（南非大羚羊，羚羊），分别。基于序列比对，麝牛中的病毒序列与MCFV-WTD最密切相关（81.5%序列同一性），努比亚北山羊中的病毒序列与CpHV-2最接近（89.3%同一性）。大羚羊中的病毒序列与AlHV-1最密切相关（85.1%同一性）。没有证据表明疾病与这些病毒有关。
Six members of the malignant catarrhal fever (MCF) virus group of ruminant rhadinoviruses have been identified to date. Four of these viruses are clearly associated with clinical disease: alcelaphine herpesvirus I (AlHV-1) carried by wildebeest (Connochaetes spp.); ovine herpesvirus 2 (OvHV-2), ubiquitous in domestic sheep; caprine herpesvirus 2 (CpHV-2), endemic in domestic goats; and the virus of unknown origin found causing classic MCF in white-tailed deer (Odocoileus virginianus; MCFV-WTD). Using serology and polymerase chain reaction with degenerate primers targeting a portion of the herpesviral DNA polymerase gene, evidence of three previously unrecognized rhadinoviruses in the MCF virus group was found in muskox (Ovibos moschatus), Nubian ibex (Capra nubiana), and gemsbok (South African oryx, Oryx gazella), respectively. Based on sequence alignment, the viral sequence in the muskox is most closely related to MCFV-WTD (81.5% sequence identity) and that in the Nubian ibex is closest to CpHV-2 (89.3% identity). The viral sequence in the gemsbok is most closely related to AlHV-1 (85.1% identity). No evidence of disease association with these viruses has been found.