Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart
Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart
复制标题
兔心脏灌注中肌钙蛋白 I 的磷酸化和肾上腺素的正性肌力作用
作者：
R. Solaro;A. Moir;S. Perry
细胞内Ca 2+浓度的变化对心肌收缩活动的调节涉及调节蛋白系统，该系统由原肌球蛋白和位于I丝的肌钙蛋白复合物组成。虽然心肌的调节蛋白系统在功能上与骨骼肌的调节蛋白系统基本相似，但两种组织中的组分不同。心脏原肌球蛋白主要由α亚基组成，而骨骼蛋白由α和β亚基组成1。肌钙蛋白I、肌钙蛋白C和肌钙蛋白T都对心肌具有特异性，因为它们具有与相应骨骼肌蛋白不同的化学和免疫化学性质2 -4。此外，心肌肌钙蛋白I和心肌肌钙蛋白C已被证明具有与其骨骼肌对应物不同的氨基酸序列3，5。
THE regulation of contractile activity in cardiac muscle by changes in the intracellular Ca2+ concentration involves the regulatory protein system, consisting of tropomyosin and the troponin complex that is located in the I filament. Although the regulatory protein system of cardiac muscle is essentially similar in function to that of skeletal muscle, the components differ in the two tissues. Cardiac tropomyosin consists principally of α subunits, whereas the skeletal protein is composed of α and β subunits1. Troponin I, troponin C and troponin T are all specific for cardiac muscle in that they have different chemical and immunochemical properties from the corresponding skeletal muscle proteins2–4. In addition, cardiac troponin I and cardiac troponin C have been shown to have different amino acid sequences from their skeletal muscle counterparts3,5.