Nocodazole, a microtubule depolymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression
Nocodazole, a microtubule depolymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression
复制标题
DOI：
10.1016/j.leukres.2005.08.009
复制
发表时间：
2006-04-01
影响因子：
2.7
通讯作者：
Wagner, SD
中科院分区：
文献类型：
--
作者：
Beswick, RW;Ambrose, HE;Wagner, SD
微管活性药物用于恶性肿瘤的治疗，其在循环细胞中的作用机制是产生有丝分裂停止，随后发生凋亡。在这项研究中，我们详细研究了微管解聚剂nocodazole诱导非循环细胞(即G(0)/G(1)，慢性淋巴细胞白血病（CLL） b细胞凋亡的特异性和机制。大多数CLL病例为敏感（IC50）
Microtubule active drugs are used in the treatment of malignancies and their mechanism of action in cycling cells is to produce mitotic arrest followed by apoptosis. In this study, we investigate in detail the specificity and mechanism by which a microtubule depolymerising agent, nocodazole, induces apoptosis in non-cyclingm, i.e. G(0)/G(1), chronic lymphocytic leukaemia (CLL) B-cells. The majority of cases of CLL are sensitive (IC50