Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum
Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum
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DOI：
10.1016/j.neures.2005.07.007
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发表时间：
2005-11-01
影响因子：
2.9
通讯作者：
Kano, M
中科院分区：
文献类型：
--
作者：
Hashimoto, K;Kano, M
啮齿类动物的小脑攀升纤维(CF)至浦肯野细胞(PC)突触为研究中枢神经系统中突触功能的生后发育和消除多余突触的机制提供了一个很好的模型。在出生时，每台PC都受到多个CFs的支配。然后，选择单一的CF投入，成熟和强化，同时剔除多余的CF。到出生后第三周结束时，大多数PC都被单个CFs所支配。这篇最新的文章旨在提供关于这一过程机制的最新研究概况。(C)2005年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Cerebellar climbing fiber (CF) to Purkinje cell (PC) synapses in rodents provides a good model to study mechanisms underlying postnatal development of synaptic functions and elimination of redundant synapses in the central nervous system. At birth, each PC is innervated by multiple CFs. Then, single CF input is selected, matured and strengthened, while surplus CFs are eliminated. By the end of the third postnatal week, most PCs become innervated by single CFs. This up-date article aims to provide an overview of recent studies on the mechanisms of this process. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.