Using MRI to assess aortic wall thickness in the multiethnic study of atherosclerosis: Distribution by race, sex, and age
Using MRI to assess aortic wall thickness in the multiethnic study of atherosclerosis: Distribution by race, sex, and age
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DOI：
10.2214/ajr.182.3.1820593
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发表时间：
2004-03-01
影响因子：
5
通讯作者：
Bluemke, DA
中科院分区：
文献类型：
--
作者：
Li, AE;Kamel, I;Bluemke, DA
OBJECTIVE.了解亚临床动脉粥样硬化的决定因素可能有助于阐明动脉粥样硬化的发病机制和指导预防策略。在这项初步研究中，我们研究了主动脉壁厚度作为亚临床动脉粥样硬化的测量指标的作用，评估了使用MRI测量主动脉壁厚度的方法，并试图通过患者种族，性别和年龄来定义主动脉壁厚度的差异。在这项前瞻性研究中，196名参与者（99名黑人，97名白色; 98名男性，98名女性）选自多种族动脉粥样硬化研究。该研究由45-84岁的无临床心血管疾病的参与者组成，他们从美国的六个研究中心招募。我们进行快速自旋回波双反转恢复MRI测量胸主动脉壁厚度。我们使用组内相关系数检验观察者间一致性，使用Mann-Whitney检验检验壁厚的性别和种族差异，使用线性回归检验年龄和壁厚之间的相关性。在MRI上测量平均和最大壁厚的重现性极佳。平均壁厚和最大壁厚随年龄增加而增加（分别为p < 0.001和p = 0.002）。男性的平均壁厚（2.32 vs 2.11 mm，p = 0.028）和平均最大壁厚（3.85 vs 3.31 mm，p = 0.010）大于女性。黑人的平均最大管壁厚度大于白人（3.74 vs 3.42 mm，p = 0.023）。MRI是测量主动脉壁厚度的可行方法，观察者之间的一致性较高。主动脉壁厚度随年龄增长而增加，也因种族和性别而异。
OBJECTIVE. Understanding the determinants of subclinical atherosclerosis may aid in elucidating the pathogenesis of atherosclerosis and guide prevention strategies. In this pilot study, we investigated the role of aortic wall thickness as a measure of subclinical atherosclerosis, assessed a method by which to measure aortic wall thickness using MRI, and attempted to define differences in aortic wall thickness by patient race, sex, and age.SUBJECTS AND METHODS. In this prospective study, 196 participants (99 black, 97 white; 98 men, 98 women) were selected from the Multiethnic Study of Atherosclerosis,. which consists of participants 45-84 years old without clinical cardiovascular disease, who were recruited from six study centers in the United States. We performed fast spin-echo double inversion recovery MRI to measure thoracic aortic wall thickness. We tested interobserver agreement using the intraclass correlation coefficient, for sex and race differences in wall thickness using the Mann-Whitney test, and for associations between age and wall thickness using linear regression.RESULTS. Reproducibility was excellent for measurements of average and maximal wall thickness on MRI. Average and maximal wall thickness increased with age (p < 0.001 and p = 0.002, respectively). Men had greater mean average wall thickness (2.32 vs 2.11 mm, p = 0.028) and mean maximal wall thickness (3.85 vs 3.31 mm, p = 0.010) than women. Blacks had greater mean maximal wall thickness than whites (3.74 vs 3.42 mm, p = 0.023).CONCLUSION. MRI is a feasible method to measure aortic wall thickness with high interobserver agreement. Aortic wall thickness increases with age and also varies by race and sex.