Impact of SARS-CoV2 on youth onset type 2 diabetes new diagnoses and severity.
Impact of SARS-CoV2 on youth onset type 2 diabetes new diagnoses and severity.
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DOI：
10.1111/1753-0407.13301
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发表时间：
2022-08
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
初步报告显示，在COVID-19大流行期间，青年发病的2型糖尿病增加。我们的目标是通过分析更长时期的趋势来扩展现有证据。我们的研究旨在描述与五年前相比，COVID-19大流行期间青年发病2型糖尿病诊断的数量，严重程度和人口统计学变化。我们对2019冠状病毒病大流行期间（2020年5月1日至2021年4月30日）和之前五年（2015年5月1日至2020年4月30日）在三级医疗中心诊断为2型糖尿病的青年（年龄≤ 21岁）进行了回顾性横断面审查。儿童按国际疾病分类编码进行识别。审查图表以确认诊断。采用卡方检验、t检验和Fisher精确检验进行分析。在大流行前，2型糖尿病的年诊断率为41-69（平均值= 54.2），而在大流行期间，诊断出159名儿童，增加了293%。这一增加导致大流行期间的发病率比高于以前，2.77比1.07（p = 0.006）。非西班牙裔黑人患者的新诊断增加最多，达490%。大流行期间就诊时的平均HbA 1c（9.5% ± 2.6）（79.9 mmol/mol ± 28.2）高于之前（8.7%±2.1）（72.1 mmol/mol ± 23.1）（p = 0.003）。在大流行期间确诊的患者中，59%接受了COVID-19检测，3人检测呈阳性。在大流行期间，2型糖尿病的新诊断增加，最明显的是非西班牙裔黑人青年。在受试者中，未发现与临床或生化COVID-19感染的显著相关性。在大流行期间，青年人发病的2型糖尿病新病例有所增加。非西班牙裔黑人青年受大流行期间青年发病2型糖尿病增加的影响最大。在受试者中，未发现与临床或生化COVID-19感染的显著相关性。 亮点
Initial reports show an increase in youth onset type 2 diabetes during the COVID‐19 pandemic. We aim to expand on existing evidence by analyzing trends over a longer period. Our study aims to describe change in the amount, severity, and demographics of youth onset type 2 diabetes diagnoses during the COVID‐19 pandemic compared to the five years before. We performed a retrospective cross‐sectional review of youth (age ≤ 21) diagnosed with type 2 diabetes during the COVID‐19 pandemic (1 May 2020–30 April 2021) and the five years before (1 May 2015–30 April 2020) at a tertiary care center. Children were identified by International Classification of Diseases codes. Charts were reviewed to confirm diagnosis. Chi‐square, t tests, and Fisher's exact tests were used for analyses. In the prepandemic era annual diagnoses of type 2 diabetes ranged from 41–69 (mean = 54.2), whereas during the pandemic period 159 children were diagnosed, an increase of 293%. The increase resulted in a higher incidence rate ratio during the pandemic than before, 2.77 versus 1.07 (p = .006). New diagnoses increased most, by 490%, in Non‐Hispanic Black patients. The average HbA1c at presentation was higher during the pandemic (9.5% ± 2.6) (79.9 mmol/mol ± 28.2) than before (8.7%±2.1) (72.1 mmol/mol ± 23.1) (p = .003). Of those diagnosed during the pandemic, 59% were tested for COVID‐19 and three tested positive. New diagnoses of type 2 diabetes increased during the pandemic, most notably in Non‐Hispanic Black youth. There was not a significant correlation found with clinical or biochemical COVID‐19 infection in those tested. There has been an increase in new cases of youth onset type 2 diabetes during the pandemic. Non‐Hispanic Black youth have been most affected the increase in youth onset type 2 diabetes during the pandemic. No significant correlation was identified with clinical or biochemical COVID‐19 infection in those tested. Highlights
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DOI：
10.1016/j.jand.2012.08.031
发表时间：
2012-12-01
影响因子：
4.8
作者：
Metallinos-Katsaras, Elizabeth;Must, Aviva;Gorman, Kathleen
通讯作者：
Gorman, Kathleen
影响因子：
6.9
作者：
von Hippel, Paul T.;Workman, Joseph
通讯作者：
Workman, Joseph
影响因子：
4.5
作者：
Chen TA;Baranowski T;Moreno JP;O'Connor TM;Hughes SO;Baranowski J;Woehler D;Kimbro RT;Johnston CA
通讯作者：
Johnston CA
影响因子：
7.3
作者：
Hamming, I;Timens, W;van Goor, H
通讯作者：
van Goor, H
影响因子：
16.2
作者：
Mayer-Davis EJ;Bell RA;Dabelea D;D'Agostino R Jr;Imperatore G;Lawrence JM;Liu L;Marcovina S;SEARCH for Diabetes in Youth Study Group
通讯作者：
SEARCH for Diabetes in Youth Study Group