Rh[III]-Catalyzed C-H Amidation Using Aroyloxycarbamates To Give N-Boc Protected Arylamines
Rh[III]-Catalyzed C-H Amidation Using Aroyloxycarbamates To Give N-Boc Protected Arylamines
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DOI：
10.1021/ol401209f
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发表时间：
2013-06-21
期刊：
影响因子：
5.2
通讯作者：
Glorius, Frank
中科院分区：
文献类型：
--
作者：
Grohmann, Christoph;Wang, Honggen;Glorius, Frank
报道了Rh（III）催化的C（sp（2））-H键的酰胺化反应。反应在温和条件下进行，具有广泛的官能团耐受性，吡啶和O-甲基异羟肟酸作为有效的导向基团，提供有价值的N-Boc保护的芳基胺（也是Fmoc和Cbz）。初步的机械实验进行了讨论。
The Rh(III)-catalyzed amidation of C(sp(2))-H bonds by the use of electron-deficient aroyloxycarbamates as efficient electrophilic amidation partners is reported. The reaction proceeded under mild conditions with broad functional group tolerance, and pyridine and O-methyl hydroxamic acids serve as efficient directing groups, giving access to valuable N-Boc protected arylamines (also Fmoc and Cbz). Preliminary mechanistic experiments are discussed.