Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.
Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.
复制标题
甲酰肽受体促进大鼠神经干细胞的迁移和分化
DOI：
10.1038/srep25946
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发表时间：
2016-05-13
影响因子：
4.6
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Wang G;Zhang L;Chen X;Xue X;Guo Q;Liu M;Zhao J
神经干细胞具有增殖、迁移和分化为三种主要神经细胞类型的特性：神经元、星形胶质细胞和/或少突胶质细胞。甲酰肽受体（Formylpeptide receptor，FXR）属于G蛋白偶联化学引诱物受体家族，在中枢神经系统（CNS）的神经元上发现。在这里，我们报告，Fpr 1和Fpr 2表达的神经干细胞检测免疫组化，RT-PCR和WB分析。此外，Fpr 1和Fpr 2通过F-actin聚合促进NSC迁移，并使NSC向神经元分化。我们的研究证明了Fpr 1和Fpr 2在神经干细胞中的独特作用，并为脑和脊髓损伤的细胞替代疗法打开了一扇新的窗口。
Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in the central nervous system (CNS). Here, we report that Fpr1 and Fpr2 are expressed on NSCs as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promoted NSC migration through F-actin polymerization and skewed NSC differentiation to neurons. Our study demonstrates a unique role of Fpr1 and Fpr2 in NSCs and opens a novel window for cell replacement therapies for brain and spinal cord injury.