Preventing labyrinthitis ossificans -: The role of steroids
Preventing labyrinthitis ossificans -: The role of steroids
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DOI：
10.1001/archotol.127.2.180
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发表时间：
2001-02-01
影响因子：
--
通讯作者：
Parisier, SC
中科院分区：
文献类型：
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作者：
Hartnick, CJ;Kim, HY;Parisier, SC
目的：为了确定一个可能的关系，在细菌性脑膜炎的诊断和骨化性asthitisossificans.Design的发展时类固醇的管理：38名儿童需要人工耳蜗植入谁提出了细菌性脑膜炎，然后开发双边深度耳聋的图表进行回顾性分析。对患者病历进行了回顾，包括诊断时的年龄、给予的抗生素类型、类固醇（地塞米松）治疗的给药、剂量和持续时间。骨化性上唇炎建立术前计算机断层扫描和/或磁共振成像和术中的结果中所描述的operation report.Patients和方法：患者38名儿童谁接受人工耳蜗植入由一个单一的高级耳鼻喉科医生细菌性脑膜炎相关的耳聋。10例患者的图表（26%）可供全面审查，这10例患者中有9例记录肺炎球菌脑膜炎和其他患者有流感嗜血杆菌型meningaemia.Results：6例谁接受类固醇治疗的时候，最初的疾病有记录的证据骨化性尿道炎无论是放射学检查或在手术的时候。所有4例接受类固醇治疗失败的患者均发生骨化性尿道炎。结果经卡方检验和t检验，差异有统计学意义（P
Objective: To identify a possible relationship between the administration of steroids at the time of diagnosis of bacterial meningitis and the development of labyrinthitis ossificans.Design: Retrospective analysis of the charts of 38 children requiring cochlear implantation who presented with bacterial meningitis and then developed bilateral profound deafness. The patients' charts were reviewed for age at diagnosis, the type of antibiotic administered, and the administration, dosage, and duration of steroid (dexamethasone) therapy. Labyrinthitis ossificans was established by preoperative computed tomographic and/or magnetic resonance imaging and by the intraoperative findings as described in the operative report.Patients and Methods: Patients were 38 children who received cochlear implantation by a single senior otolaryngologist for bacterial meningitis-related deafness. Ten patients' charts (26%) were available for full review; 9 of these 10 patients had documented pneumococcal meningitis and the other patient had Haemophilus influenzae-type meningitis.Results: One of the 6 patients who received steroid therapy at the time of initial illness had documented evidence of labyrinthitis ossificans either radiographically or at the time of surgery. All 4 patients who failed to receive steroid therapy developed labyrinthitis ossificans. The results achieve statistical significance by chi (2) analysis and a t test (P