Hepatotoxicity of salicylates in monolayer cell cultures.
Hepatotoxicity of salicylates in monolayer cell cultures.
复制标题
单层细胞培养物中水杨酸盐的肝毒性。
DOI：
10.1016/0016-5085(78)90797-7
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发表时间：
1978
期刊：
影响因子：
29.4
通讯作者：
S. Hammar
中科院分区：
文献类型：
--
作者：
K. Tolman;P. Peterson;P. Gray;S. Hammar
通过测定培养上清液中乳酸脱氢酶活性来评价不同剂量水杨酸钠对单层培养大鼠肝细胞的影响。用电子显微镜观察细胞的形态变化。此外，还评价了不同白蛋白浓度对细胞毒性的影响。乳酸脱氢酶浓度随着水杨酸盐剂量的增加而增加，最高可达每分升40毫克。高浓度的白蛋白与水杨酸盐的毒性降低有关。这些结果表明，水杨酸盐诱导的肝损伤与剂量有关，并可能受血清白蛋白水平的影响。
The influence of graded doses of sodium salicylate on rat liver cells cultured in monolayers was assessed by measuring lactic dehydrogenase activity in a culture media after incubation. Morphological alterations were studied by electron microscopy. The influence of different albumin concentrations in the media on toxicity was also evaluated. Lactic dehydrogenase concentrations rose with increasing doses of salicylate up to 40 mg per dl. High concentrations of albumin were associated with reduced salicylate toxicity. These findings suggest that salicylate-induced hepatic injury is dose related and may be influenced by serum albumin levels.