Outbreak of human listeriosis associated with tomme cheese in northwest Switzerland, 2005.
Outbreak of human listeriosis associated with tomme cheese in northwest Switzerland, 2005.
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DOI：
10.2807/esm.11.06.00633-en
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Waespi, U
中科院分区：
文献类型：
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作者：
Bille, J;Blanc, D S;Waespi, U
在2005年春季的8周期间，在瑞士西北部的一个小地区（15万居民）报告了10例李斯特菌病。8例发生在因菌血症而患病的免疫功能低下的老年患者中（3例死亡），2例发生在败血性流产的孕妇中。在2005年春季的8周期间，瑞士西北部的一个小地区（15万居民）报告了10例李斯特菌病。8例发生在因菌血症而患病的免疫功能低下的老年患者中（3例死亡），2例发生在败血性流产的孕妇中。所有病例都是由1/2a血清型分离株感染PFGE发现的两种脉冲病毒之一引起的。对患者的采访很快显示，当地制造和分发的软奶酪（称为“tomme”）是导致疫情的食物来源。该奶酪和同一工厂生产的黄油的样品显示，同一pulsovar中单核细胞增生李斯特菌sv 1/2a的含量分别为1000-10 000和10-100 cfu/g。迅速停产、市场召回产品以及公众警报终止了疫情。然而，在产品召回后10天内，报告了两例由同一菌株引起的发热性肠胃炎病例。受污染奶酪的有限分布区域以及当地医生、医学微生物学家和食品卫生服务机构的合作，都有助于迅速和成功地进行调查。这次李斯特菌病的小规模暴发加强了对以实验室为基础的快速分型监测系统以及医生和微生物学家之间合作的需求。
During an eight week period in spring 2005, 10 cases of listeriosis were reported in a small area of northwest Switzerland (150 000 inhabitants). Eight cases were in older immunocompromised patients who became ill with bacteraemia (three deaths), and two cases were in pregnant women who had septic abortion.During an eight week period in spring 2005, 10 cases of listeriosis were reported in a small area of northwest Switzerland (150,000 inhabitants). Eight cases were in older immunocompromised patients who became ill with bacteraemia (three deaths), and two cases were in pregnant women who had septic abortion. All cases were due to a serotype 1/2a isolate with one of two pulsovars found by PFGE. Patient interviews quickly revealed that a locally made and distributed soft cheese (known as 'tomme') was the food source responsible for the outbreak. Samples of this cheese, and of butter made in the same factory, revealed Listeria monocytogenes sv 1/2a of the same pulsovar in amounts of 1000-10 000 and 10-100 cfu/g, respectively. The prompt suspension of production, the market recall of the product, and a public alert terminated the outbreak. However, two cases of febrile gastroenteritis due to the same strains were reported within 10 days of product recall. The restricted distribution area of the contaminated cheese and the collaboration of local physicians, medical microbiologists and food health services all contributed to a rapid and successful investigation. This small outbreak of listeriosis reinforces the need for a laboratory-based surveillance system with rapid typing, as well as collaboration between physicians and microbiologists.