Composite bounds on the elastic modulus of bone
Composite bounds on the elastic modulus of bone
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DOI：
10.1016/j.jbiomech.2008.05.018
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发表时间：
2008-08-07
影响因子：
2.4
通讯作者：
Boyde, Alan
中科院分区：
文献类型：
--
作者：
Oyen, Michelle L.;Ferguson, Virginia L.;Boyde, Alan
通过了解矿物质含量和力学功能之间的联系，可以在一些骨疾病的诊断和治疗方面取得进展。按体积计算，骨大约有一半是水合蛋白网络，其余部分是羟基磷灰石的生物矿物类似物。在目前的工作中，使用纳米压痕对机械性能和骨矿物体积分数进行了配对测量。通过定量背散射电子成像，对六种不同类型的正常和异常骨样本进行了计算。局部弹性模量根据矿物组分绘制，并与两相复合材料的工程界预测值进行了比较。跨越复合材料边界的实验数据显示，机械刚度和骨成分之间没有一对一的关系，排除了任何单一的、简单的纳米尺度骨复合材料模型的可能性。(C) 2008 Elsevier Ltd版权所有。
Advances in diagnosis and treatment of some bone disorders can be made by understanding the linkage between mineral content and mechanical function. Bone is approximately half by volume a hydrated protein network, and the remainder is a biomineral analogue Of hydroxyapatite. In the current work, paired measurements of mechanical properties, using nanoindentation, and of bone mineral volume fraction. computed from quantitative back-scattered electron imaging, were made on six different types of normal and outlier bone samples. Local elastic modulus Was Plotted against mineral fraction and compared with predictions of engineering bounds for a two-phase composite material. Experimental data spanning the composite bounds showed no one-to-one relationship between mechanical stiffness and bone composition, excluding the possibility of any single, simple composites model for bone at nanometer length-scales. (C) 2008 Elsevier Ltd. All rights reserved.