Mechanics of cup-shaped caveolae
Mechanics of cup-shaped caveolae
复制标题
杯状小窝的力学
DOI：
10.1103/physreve.104.l022401
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发表时间：
2021
影响因子：
2.4
通讯作者：
Haselwandter, Christoph A.
中科院分区：
文献类型：
--
作者：
Shrestha, Ahis;Pinaud, Fabien;Haselwandter, Christoph A.
小泡是由特定的脂质和蛋白质组成的细胞膜内陷，随着膜张力的增加而变平。超分辨率光学显微镜和电子显微镜显示，小泡可以有各种各样的杯状形状。我们在这里表明，在与细胞膜相关的膜张力范围内，膜张力和膜弯曲之间的竞争产生了与实验观察到的类似的杯状小泡。我们发现，小窝的形状及其对膜张力变化的敏感性在很大程度上取决于小窝的自发曲率和小窝域的大小。我们的研究结果表明，小泡形状的异质性产生了小泡对细胞膜机械扰动的交错反应，这可能有助于在被认为与细胞膜相关的大范围尺度上调节膜张力。
Caveolae are cell membrane invaginations of defined lipid and protein composition that flatten with increasing membrane tension. Super-resolution light microscopy and electron microscopy have revealed that caveolae can take a variety of cuplike shapes. We show here that, for the range in membrane tension relevant for cell membranes, the competition between membrane tension and membrane bending yields caveolae with cuplike shapes similar to those observed experimentally. We find that the caveola shape and its sensitivity to changes in membrane tension can depend strongly on the caveola spontaneous curvature and on the size of caveola domains. Our results suggest that heterogeneity in caveola shape produces a staggered response of caveolae to mechanical perturbations of the cell membrane, which may facilitate regulation of membrane tension over the wide range of scales thought to be relevant for cell membranes.